Publicação
Biocatalytic nanobots: enhancing reactive oxygen species neutralisation for targeted therapy in inflammatory bowel disease
| Resumo: | Background & idea: Inflammatory bowel disease (IBD) is marked by chronic intestinal inflammation and an overproduction of reactive oxygen species (ROS) within the gastrointestinal mucosa. Elevated ROS levels contribute to tissue damage and impair mucosal healing, thereby intensifying the inflammatory process. Conventional treatments, such as corticosteroids and immunosuppressants, primarily target systemic inflammation but are limited in addressing the localized oxidative stress characteristic of IBD. To overcome these limitations, our study introduces a polymeric biocatalytic nanobot (NB) system designed to combine efficient propulsion with ROS neutralisation. The NB is built around a chitosan core with mucoadhesive properties, which promotes prolonged retention at inflamed mucosal surfaces and may also enhance the delivery of bioactive compounds. |
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| Autores principais: | Sousa, Ana Sofia |
| Outros Autores: | Mayer, André; Reis, Celso A.; Pintado, Maria Manuela; Coscueta, Ezequiel R. |
| Assunto: | IBD |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | póster não publicado nas atas da conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Católica Portuguesa |
| Idioma: | inglês |
| Origem: | Veritati - Repositório Institucional da Universidade Católica Portuguesa |
| Resumo: | Background & idea: Inflammatory bowel disease (IBD) is marked by chronic intestinal inflammation and an overproduction of reactive oxygen species (ROS) within the gastrointestinal mucosa. Elevated ROS levels contribute to tissue damage and impair mucosal healing, thereby intensifying the inflammatory process. Conventional treatments, such as corticosteroids and immunosuppressants, primarily target systemic inflammation but are limited in addressing the localized oxidative stress characteristic of IBD. To overcome these limitations, our study introduces a polymeric biocatalytic nanobot (NB) system designed to combine efficient propulsion with ROS neutralisation. The NB is built around a chitosan core with mucoadhesive properties, which promotes prolonged retention at inflamed mucosal surfaces and may also enhance the delivery of bioactive compounds. |
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Atividades financiadas
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