Publication
Effect of hydrocortisone presence in aggregates size in cyclodextrin aqueous solutions
| Summary: | Cyclodextrins are oligosaccharides that have been extensively used in several industries, ranging from the food industry to the pharmaceutical industry. However, despite they have been studied for over 100 years, they are still regarded as novel pharmaceutical excipients. Cyclodextrins are particularly interesting because of their ability to form inclusion complexes with poorly-water soluble drugs and so to increase drug solubility and bioavailability. There are several routes for drug delivery by cyclodextrins (oral, sublingual, ocular, nasal, pulmonary, parenteral and dermic) and all of them have been carefully studied and improved in order to obtain safe formulations for human administration. It is known that cyclodextrins can form aggregates amongst each other in aqueous solutions, both as free molecule or when taking part in an inclusion complex. Although, it is not well comprehended yet what forces drive the aggregates formation or which shape or size it can present. It is also necessary to investigate its stability and safety. The work here presented was centered in the observation of the behavior of α- and β-cyclodextrins complexes with the objective to understand the differences between aggregates formed at specific environmental conditions, its stability and whether the presence of a drug influences the aggregate formation. |
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| Main Authors: | Malvas, Ana Rita Paiva |
| Subject: | Cyclodextrins Drug delivery Inclusion complexes Aggregates Mestrado Integrado - 2014 |
| Year: | 2014 |
| Country: | Portugal |
| Document type: | master thesis |
| Access type: | restricted access |
| Associated institution: | Universidade de Lisboa |
| Language: | English |
| Origin: | Repositório da Universidade de Lisboa |
| Summary: | Cyclodextrins are oligosaccharides that have been extensively used in several industries, ranging from the food industry to the pharmaceutical industry. However, despite they have been studied for over 100 years, they are still regarded as novel pharmaceutical excipients. Cyclodextrins are particularly interesting because of their ability to form inclusion complexes with poorly-water soluble drugs and so to increase drug solubility and bioavailability. There are several routes for drug delivery by cyclodextrins (oral, sublingual, ocular, nasal, pulmonary, parenteral and dermic) and all of them have been carefully studied and improved in order to obtain safe formulations for human administration. It is known that cyclodextrins can form aggregates amongst each other in aqueous solutions, both as free molecule or when taking part in an inclusion complex. Although, it is not well comprehended yet what forces drive the aggregates formation or which shape or size it can present. It is also necessary to investigate its stability and safety. The work here presented was centered in the observation of the behavior of α- and β-cyclodextrins complexes with the objective to understand the differences between aggregates formed at specific environmental conditions, its stability and whether the presence of a drug influences the aggregate formation. |
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