Publicação

Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study

Detalhes bibliográficos
Resumo:	The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pKa of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.
Autores principais:	de Castro, Baltazar
Outros Autores:	Gameiro, Paula; Guimarães, Carla; Lima, José L.F.C.; Reis, Salette
Assunto:	Adrenergic beta-Antagonists Benzodiazepines Electrochemistry Hydrogen-Ion Concentration Micelles Models, Chemical Sodium Dodecyl Sulfate Spectrophotometry, Ultraviolet
Ano:	1998
País:	Portugal
Tipo de documento:	artigo
Tipo de acesso:	acesso restrito
Instituição associada:	Universidade Fernando Pessoa
Idioma:	inglês
Origem:	Repositório Institucional da Fernando Pessoa

Descrição
Resumo:	The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pKa of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.

Não foram encontrados projetos financiados.