Publicação
Hair as a monitoring tool for psychoactive substances
| Resumo: | The global prevalence of substance use and its severe health, social, and economic consequences remain significant public health concerns. The continuous emergence of new psychoactive substances (NPS), alongside the widespread use of traditional drugs, exacerbates the challenges faced by forensic and clinical toxicologists. These substances often evade conventional detection methods due to their rapid evolution, posing significant risks to users and complicating monitoring efforts. Understanding substance use patterns and their impacts is essential for informing prevention strategies, shaping public policies, and implementing harm reduction initiatives. Hair analysis has emerged as a powerful tool in toxicological investigations, offering unique advantages over traditional biological matrices such as blood and urine. Its extended detection window enables the assessment of chronic and historical drug use, while its resistance to adulteration ensures reliability. As a non-invasive collection method, hair analysis facilitates large-scale studies, making it particularly suitable for exploring poly-drug use and evaluating the prevalence of both classical drugs and NPS across diverse populations. Quantitative hair analysis complements self-reported data, addressing discrepancies and enhancing the accuracy of substance use research. [...] |
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| Autores principais: | Simão, Ana Aysa Rocha da |
| Assunto: | Cabelo Drogas de abuso Cromatografia líquida acoplada à espectrometria de massa em tandem (LC-MS/MS) Cromatografia gasosa acoplada à espectrometria de massa em tandem (GC-MS/MS) Microextracão em seringa empacotada (MEPS) Monitorização de drogas Substâncias Psicoativas Toxicologia Forense Hair analysis Drugs of abuse Liquid chromatography-tandem mass spectrometry (LCMS/ MS) Forensic toxicology |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso embargado |
| Instituição associada: | Universidade da Beira Interior |
| Idioma: | inglês |
| Origem: | uBibliorum |
| Resumo: | The global prevalence of substance use and its severe health, social, and economic consequences remain significant public health concerns. The continuous emergence of new psychoactive substances (NPS), alongside the widespread use of traditional drugs, exacerbates the challenges faced by forensic and clinical toxicologists. These substances often evade conventional detection methods due to their rapid evolution, posing significant risks to users and complicating monitoring efforts. Understanding substance use patterns and their impacts is essential for informing prevention strategies, shaping public policies, and implementing harm reduction initiatives. Hair analysis has emerged as a powerful tool in toxicological investigations, offering unique advantages over traditional biological matrices such as blood and urine. Its extended detection window enables the assessment of chronic and historical drug use, while its resistance to adulteration ensures reliability. As a non-invasive collection method, hair analysis facilitates large-scale studies, making it particularly suitable for exploring poly-drug use and evaluating the prevalence of both classical drugs and NPS across diverse populations. Quantitative hair analysis complements self-reported data, addressing discrepancies and enhancing the accuracy of substance use research. [...] |
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