Publicação
The utility of PET/CT with 18F-FDG in the study of Hodgkin's lymphoma and non-Hodgkin's lymphoma
| Resumo: | Lymphomas are tumors established in the lymphatic system. Due to their heterogeneity, they can be classified as Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL), presenting each type of lymphoma, different prognosis, and chemotherapeutic response. Currently, Photon Emission Tomography/Computed Tomography (PET/CT) is considered the "image" of excellence in the study of this pathology. In this context, it is of interest in this article to verify the usefulness of the PET/CT technique and to correlate the value of Standard Uptake Value (SUV) obtained by PET with the histological stage of lymphoma and the response to chemotherapeutic treatment. Methodology - We studied retrospectively 356 studies for 231 patients that did a PET/CT for staging, or evaluation of a mass or of the response to treatment. After administration of an average activity of 18F-FDG of 288.6 MBq, images were acquired on a PET/CT GE Discovery ST. These results were compared with the clinical data of patients. Results - Significant differences were found between age vs type of lymphoma. No significant differences were found between: the value of SUVmaxim nodes, extra-nodal lesions, and their value of SUV for the type of lymphoma. It verified the influence of PET/CT in the alteration of the stage of lymphoma as well as the therapeutic decision. Finally were found respectively the following values of sensitivity, specificity, and accuracy: were 98%, 79%, and 88%. Conclusions - The results show the importance of imaging PET/CT in evaluating the stage of the tumor and its role in monitoring and change of therapeutic decisions. |
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| Autores principais: | Milhões, Marta |
| Outros Autores: | Rafael Infante, José; Rayo Madrid, Juan; Garcia, L. B.; Vieira, Lina |
| Assunto: | PET/CT 18F-FDG Linfoma Hodgkin Linfoma não Hodgkin PET/CT 18F-FDG Hodgkin's lymphoma Non-Hodgkin's lymphoma |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa |
| Idioma: | português |
| Origem: | Saúde & Tecnologia |
| Resumo: | Lymphomas are tumors established in the lymphatic system. Due to their heterogeneity, they can be classified as Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL), presenting each type of lymphoma, different prognosis, and chemotherapeutic response. Currently, Photon Emission Tomography/Computed Tomography (PET/CT) is considered the "image" of excellence in the study of this pathology. In this context, it is of interest in this article to verify the usefulness of the PET/CT technique and to correlate the value of Standard Uptake Value (SUV) obtained by PET with the histological stage of lymphoma and the response to chemotherapeutic treatment. Methodology - We studied retrospectively 356 studies for 231 patients that did a PET/CT for staging, or evaluation of a mass or of the response to treatment. After administration of an average activity of 18F-FDG of 288.6 MBq, images were acquired on a PET/CT GE Discovery ST. These results were compared with the clinical data of patients. Results - Significant differences were found between age vs type of lymphoma. No significant differences were found between: the value of SUVmaxim nodes, extra-nodal lesions, and their value of SUV for the type of lymphoma. It verified the influence of PET/CT in the alteration of the stage of lymphoma as well as the therapeutic decision. Finally were found respectively the following values of sensitivity, specificity, and accuracy: were 98%, 79%, and 88%. Conclusions - The results show the importance of imaging PET/CT in evaluating the stage of the tumor and its role in monitoring and change of therapeutic decisions. |
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