Publicação
Chronic rhinossinusitis with nasal polyps (CRSwNP) biopsy – when, how and why?
| Resumo: | Objective: To assess the impact of nasal tissue neutrophilia on dupilumab response in severe, uncontrolled CRSwNP. Methodology: Retrospective study, 23 CRSwNP patients on dupilumab assessed at baseline and 6 months. Systemic IgE and eosinophilia, tissue eosinophilia and neutrophilia were recorded. Evaluation of Sino-nasal Outcome Test (SNOT-22), Visual Analogue Scale (VAS) total symptoms, Nasal Polyp Score (SPN), Barcelona Smell Test 24 (BAST-24), Nasal Congestion Score (SCN), and Smell Loss Score (SPO). Results: Mean tissue neutrophil count was 2±2.3, ranging from 0 to 8 per high-power field. Correlation was observed between tissue neutrophilia and SPO variation (r= 0.464, p = 0.034) and direct correlations between tecidual eosinophilia and neutrophilia (r=0.595, p=0.004) and between tecidual neutrophilia and sistemic IgE (r=0.548, p=0.010). Conclusion: Higher neutrophil levels appear linked to resistance to dupilumab, with less improvement in SPO. Sample size limits data reliability, warranting further studies with larger samples. |
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| Autores principais: | Bulha, Margarida |
| Outros Autores: | V. Dias, Diogo; Padrão, Miguel; Cales, Sofia; Eloi, Isa; Augusto, Sandra; Azevedo, Luísa |
| Assunto: | pólipos nasais neutrófilos eosinófilos rinossinusite biológicos Nasal polyps neutrophils eosinophils rhinossinusitis |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Sociedade Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço |
| Idioma: | português inglês |
| Origem: | Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço |
| Resumo: | Objective: To assess the impact of nasal tissue neutrophilia on dupilumab response in severe, uncontrolled CRSwNP. Methodology: Retrospective study, 23 CRSwNP patients on dupilumab assessed at baseline and 6 months. Systemic IgE and eosinophilia, tissue eosinophilia and neutrophilia were recorded. Evaluation of Sino-nasal Outcome Test (SNOT-22), Visual Analogue Scale (VAS) total symptoms, Nasal Polyp Score (SPN), Barcelona Smell Test 24 (BAST-24), Nasal Congestion Score (SCN), and Smell Loss Score (SPO). Results: Mean tissue neutrophil count was 2±2.3, ranging from 0 to 8 per high-power field. Correlation was observed between tissue neutrophilia and SPO variation (r= 0.464, p = 0.034) and direct correlations between tecidual eosinophilia and neutrophilia (r=0.595, p=0.004) and between tecidual neutrophilia and sistemic IgE (r=0.548, p=0.010). Conclusion: Higher neutrophil levels appear linked to resistance to dupilumab, with less improvement in SPO. Sample size limits data reliability, warranting further studies with larger samples. |
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