Publicação
Hiperbaric oxigen therapy. Historical perspective, physiological mechanisms and clinical applications
| Resumo: | Hyperbaric oxygen therapy (HBOT) is defined as a treatment mode which involves the breathing of pure oxygen (100% O2) at an ambient pressure higher than the atmospheric one measured at the sea level.The treatments are performed with the patients breathing pure oxygen, entirely enclosed in sealed chambers, pressurized with air (multiplace chambers) or with oxygen (monoplace chambers), at a pressure greater than one atmosphere. Multiple physiological mechanisms, which are activated as a result of hyperbaric oxygenation (mechanical effect of increased pressure, toxic gas increased wash out, hyperoxygenation, vasoconstriction, fibroblast proliferation, angiogenesis, leukocyte oxidative bacterial killing, toxin inhibition, bacteriostasis, bacterial killing, antibiotic synergy) explain the many beneficial effects of HBOT in several pathological conditions, caused, worsened or perpetuated by hypoxia or gas bubbles trapped in the body, such as: decompression sickness, air embolus syndrome, carbon monoxide intoxication and acute cyanide poisoning, clostridial gas gangrene, necrotizing soft-tissue infections, chronic osteomyelitis, chronic wounds, radiation-induced injury, crush injuries, compartment syndrome, graft and flap salvage, oedema, sepsis, acute burns, severe blood loss anemia, and many others.The present work provides an overview concerning some historical aspects, physiological effects, clinical applications, and secondary effects of HBOT. |
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| Autores principais: | Albuquerque e Sousa, J. G. |
| Assunto: | Hiperbárico oxigénio história fisiologia terapêutica aplicações Hyperbaric oxygen history physiology therapy applications |
| Ano: | 2007 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Sociedade Portuguesa de Medicina Interna |
| Idioma: | português |
| Origem: | Revista Portuguesa de Medicina Interna |
| Resumo: | Hyperbaric oxygen therapy (HBOT) is defined as a treatment mode which involves the breathing of pure oxygen (100% O2) at an ambient pressure higher than the atmospheric one measured at the sea level.The treatments are performed with the patients breathing pure oxygen, entirely enclosed in sealed chambers, pressurized with air (multiplace chambers) or with oxygen (monoplace chambers), at a pressure greater than one atmosphere. Multiple physiological mechanisms, which are activated as a result of hyperbaric oxygenation (mechanical effect of increased pressure, toxic gas increased wash out, hyperoxygenation, vasoconstriction, fibroblast proliferation, angiogenesis, leukocyte oxidative bacterial killing, toxin inhibition, bacteriostasis, bacterial killing, antibiotic synergy) explain the many beneficial effects of HBOT in several pathological conditions, caused, worsened or perpetuated by hypoxia or gas bubbles trapped in the body, such as: decompression sickness, air embolus syndrome, carbon monoxide intoxication and acute cyanide poisoning, clostridial gas gangrene, necrotizing soft-tissue infections, chronic osteomyelitis, chronic wounds, radiation-induced injury, crush injuries, compartment syndrome, graft and flap salvage, oedema, sepsis, acute burns, severe blood loss anemia, and many others.The present work provides an overview concerning some historical aspects, physiological effects, clinical applications, and secondary effects of HBOT. |
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