Publicação
Fluoroquinolonas
| Resumo: | Fluoroquinolones are synthetic compounds, structurally related to nalidixic acid. Its mechanism of action involves inhibition of bacterial DNA girase. They have a broad spectrum of activity. They are highly active against Enterobacteriaceae and also active against some strains of Pseudomonas aeruginosa and Staphilococcus sp., however recent reports indicate increasing resistance. They have poor activity against streptococci and anaerobes. These agents exhibited excelknt oral absorption, good tissue distribution and are excreted primarily by way of the kidney. The incidence of adverse effects to fluoroquinolones appears to be low. The most common are gastrointesti nal reactions, followed by central nervous system disorders. Hypersensivity reactions occur occasionally. Fluoroquinolones interact with a number of other agents, with potential clinicai manifestations, such as antacids, theophylline, warf arine. The bioavailability after oral administration allows the use of these agents without loss of efficacity, when compared with IV administration, thus reducing substantially the treatment cost. |
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| Autores principais: | Morais Almeida, Maria da Graça |
| Outros Autores: | Machado, Maria José |
| Assunto: | fluoroquinolonas antimicrobianos norfloxacina ciprofloxacina ofloxacina pefloxacina fluoroquinolones antimicrobials norfloxacin ofloxacin pefloxacin ciprofloxacin |
| Ano: | 1994 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Sociedade Portuguesa de Medicina Interna |
| Idioma: | português |
| Origem: | Revista Portuguesa de Medicina Interna |
| Resumo: | Fluoroquinolones are synthetic compounds, structurally related to nalidixic acid. Its mechanism of action involves inhibition of bacterial DNA girase. They have a broad spectrum of activity. They are highly active against Enterobacteriaceae and also active against some strains of Pseudomonas aeruginosa and Staphilococcus sp., however recent reports indicate increasing resistance. They have poor activity against streptococci and anaerobes. These agents exhibited excelknt oral absorption, good tissue distribution and are excreted primarily by way of the kidney. The incidence of adverse effects to fluoroquinolones appears to be low. The most common are gastrointesti nal reactions, followed by central nervous system disorders. Hypersensivity reactions occur occasionally. Fluoroquinolones interact with a number of other agents, with potential clinicai manifestations, such as antacids, theophylline, warf arine. The bioavailability after oral administration allows the use of these agents without loss of efficacity, when compared with IV administration, thus reducing substantially the treatment cost. |
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