Publicação
Solvent assessment and selection in terms of sustainability, performance, and cost: Design of a solvent database in a pharmaceutical environment
| Resumo: | Increased environmental awareness has, since the end of the 1980s, helped shift the paradigm from waste remediation to waste prevention. The introduction of the green chemistry concept and the publication of the twelve principles in the 1990s has been particularly embraced by the pharmaceutical industry, where typically between 25 and 100 kilograms of waste are generated per kilogram of product (ratio known as the E-factor). In this context, several manuals and guides that intend to evaluate solvents and facilitate their selection have been released, published both by individual companies (e.g., Pfizer, GSK, AstraZeneca) and working groups (e.g., ACS GCI-PR, CHEM21). In alignment with these efforts, a novel solvent selection and assessment tool was developed, tailored to suit Hovione’s unique context. The target audience was defined as anyone working with solvents, but particularly scientists looking to choose solvents for new or existing applications. A list of 50 solvents currently in use in Hovione was compiled and served as the basis for the database. For each entry, a list of 49 various chemical, thermodynamical, environmental, and regulatory data points was included. Furthermore, the tool incorporated a new unified assessment method across four categories, considering the danger that the solvent poses to workers’ health, the risk to the process safety, the environmental impact, and a sustainability analysis. Each evaluation was customizable by the user, in order to prioritize specific aspects of each exercise. In addition, each solvent was then ranked as recommended, problematic, hazardous, or highly hazardous. The final recommendations provided by the algorithms included in the tool correlated well with recommendations from other published solvent guides. These smaller assessments and final recommendations will aid scientists in comparing solvents against each other, as well as help them consider precautionary steps in case a contentious solvent is chosen for an application. |
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| Autores principais: | Obregón Gutiérrez, Gisela |
| Assunto: | Solvent selection tool Solvent assessment Green chemistry Sustainability |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Algarve |
| Idioma: | inglês |
| Origem: | Sapientia - Universidade do Algarve |
| Resumo: | Increased environmental awareness has, since the end of the 1980s, helped shift the paradigm from waste remediation to waste prevention. The introduction of the green chemistry concept and the publication of the twelve principles in the 1990s has been particularly embraced by the pharmaceutical industry, where typically between 25 and 100 kilograms of waste are generated per kilogram of product (ratio known as the E-factor). In this context, several manuals and guides that intend to evaluate solvents and facilitate their selection have been released, published both by individual companies (e.g., Pfizer, GSK, AstraZeneca) and working groups (e.g., ACS GCI-PR, CHEM21). In alignment with these efforts, a novel solvent selection and assessment tool was developed, tailored to suit Hovione’s unique context. The target audience was defined as anyone working with solvents, but particularly scientists looking to choose solvents for new or existing applications. A list of 50 solvents currently in use in Hovione was compiled and served as the basis for the database. For each entry, a list of 49 various chemical, thermodynamical, environmental, and regulatory data points was included. Furthermore, the tool incorporated a new unified assessment method across four categories, considering the danger that the solvent poses to workers’ health, the risk to the process safety, the environmental impact, and a sustainability analysis. Each evaluation was customizable by the user, in order to prioritize specific aspects of each exercise. In addition, each solvent was then ranked as recommended, problematic, hazardous, or highly hazardous. The final recommendations provided by the algorithms included in the tool correlated well with recommendations from other published solvent guides. These smaller assessments and final recommendations will aid scientists in comparing solvents against each other, as well as help them consider precautionary steps in case a contentious solvent is chosen for an application. |
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Atividades financiadas
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