Detalhes bibliográficos
| Resumo: | We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene. |
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| Autores principais: | personCanario, Adelino V. M. |
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| Outros Autores: | Rotllant, J.; personFuentes, J.; personGuerreiro, P. M.; Teodósio, H. R.; personPower, Deborah; Clark, M. S. |
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| Assunto: | Parathyroid hormone Parathyroid hormone-related peptide Calciotropic Receptor Adenylate cyclase Phospholipase C |
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| Ano: | 2006 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Algarve |
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| Idioma: | inglês |
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| Origem: | Sapientia - Universidade do Algarve |
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