Detalhes bibliográficos
| Resumo: | Proopiomelanocorticotrophin (POMC) in vertebrates is produced in the pituitary gland and undergoes post-translational processing to give rise to a range of biologically active peptides. Teleosts possess 2–3 different POMC transcripts which have been proposed to have originated from a whole or partial genome duplication. In the present study 2 transcripts of gilthead sea bream POMC (sbPOMC-a1 and a2) were cloned and characterised. sbPOMC-a1 is expressed principally in the melanotroph cells of the pars intermedia (PI) and sbPOMC-a2 is expressed in the corticotroph cells of the rostral pars distalis and probably also in the PI. The 2 sbPOMC transcripts have a differential tissue distribution in extra-pituitary sites. An appraisal of POMC evolution indicates sbPOMCs belong to one of the two main clades that exist in teleosts and that overall a non conservative process of gene loss occurred in this infraclass. |
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| Autores principais: | personCardoso, João |
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| Outros Autores: | Laiz-Carrión, R.; personLouro, Bruno; personSilva, Nádia; personCanario, Adelino V. M.; Mancera, J. M.; personPower, Deborah |
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| Assunto: | Ectopic expression Evolution Gene duplication Pituitary POMC Sub-functionalization |
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| Ano: | 2011 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Algarve |
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| Idioma: | inglês |
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| Origem: | Sapientia - Universidade do Algarve |
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