Detalhes bibliográficos
| Resumo: | Toll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in nonmucosal dendritic cells (DCs) enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown that the simultaneous activation of nonmucosal DCs through TLR2 and TLR4 maintains such capacity while reinforcing the polarization of primed CD4+ T cells towards Th1. Here, we observed that TLR2/TLR4 stimulation of aged DCs leads to the production of less TNFα and more IL-10 and that CD4+ T cells primed by those DCs express lower levels of the mucosal homing receptor CCR9 and produce less type-1 (IFNγ) and more type-2 (IL-4 and IL-13) cytokines. These results emphasize the importance of considering the age-related alterations in DC function when developing novel immunomodulation strategies that rely on the DC-T cell crosstalk through stimulation of pattern recognition receptors. |
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| Autores principais: | Zúquete, Sara |
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| Outros Autores: | Ferreira, Mariana; Delgado, Inês L.S.; Rosa, Maria Teresa; Mendes, Ana Catarina; Santos, Dulce; Nolasco, Sofia; Graca, Luis; Leitão, Alexandre; Basto, Afonso P. |
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| Assunto: | aging dendritic cells intestine toll-like receptor 2 toll-like receptor 4 Immunology and Allergy Immunology Cell Biology |
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| Ano: | 2025 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade Nova de Lisboa |
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| Idioma: | inglês |
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| Origem: | Repositório Institucional da UNL |
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