Publicação
Preparation And Characterisation Of Biopolymeric Membranes Incorporating Deep Eutectic Solvents For Wound Dressing Applications
| Resumo: | The skin serves as a vital physiological barrier; however, it remains susceptible to acute and chronic wounds. The healing process requires the coordinated progression of complex biological phases, and conventional wound dressings, such as gauze, offer limited curing support and contribute to environmental concerns due to their reliance on non-biodegradable polymers and toxic solvents. These challenges have caused an increasing interest in sustainable alternatives, particularly the use of biopolymers and deep eutectic solvents (DES), which align with green chemistry principles and offer favourable biocompatibility and biodegradability profiles. This research addresses the development of biopolymeric membranes incorporating DES for transdermal drug delivery, using diclofenac as an anti- inflammatory active pharmaceutical ingredient (API). The study explores six DES formulations prepared from biocompatible components, evaluates their properties, and integrates them into membranes based on chitosan (CS), cellulose acetate (CA), and polylactic acid (PLA). The membranes were characterised in terms of chemical interactions (FTIR-ATR), morphology (SEM), wettability (contact angle), hydrophilicity (swelling degree), mechanical properties (puncture testing), drug release profile (UV–VIS), and gas permeability (oxygen and carbon dioxide). The results demonstrate that DES incorporation modulates membrane properties. Chitosan membranes exhibited higher puncture resistance than some commercial dressings, with high drug release rates and enhanced hydrophilicity; however, they showed limited aqueous stability and lower gas permeability. PLA and CA membranes achieved more controlled swelling, with mechanical properties suitable for biomedical use, and a greater aqueous stability by comparison. The findings highlight the potential of DES-based biopolymeric membranes as sustainable wound dressing systems capable of controlled drug delivery. |
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| Autores principais: | Luna Gazcón, Daniela Guadalupe |
| Assunto: | Deep eutectic solvents biopolymers active pharmaceutical ingredients biopolymeric membranes |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | The skin serves as a vital physiological barrier; however, it remains susceptible to acute and chronic wounds. The healing process requires the coordinated progression of complex biological phases, and conventional wound dressings, such as gauze, offer limited curing support and contribute to environmental concerns due to their reliance on non-biodegradable polymers and toxic solvents. These challenges have caused an increasing interest in sustainable alternatives, particularly the use of biopolymers and deep eutectic solvents (DES), which align with green chemistry principles and offer favourable biocompatibility and biodegradability profiles. This research addresses the development of biopolymeric membranes incorporating DES for transdermal drug delivery, using diclofenac as an anti- inflammatory active pharmaceutical ingredient (API). The study explores six DES formulations prepared from biocompatible components, evaluates their properties, and integrates them into membranes based on chitosan (CS), cellulose acetate (CA), and polylactic acid (PLA). The membranes were characterised in terms of chemical interactions (FTIR-ATR), morphology (SEM), wettability (contact angle), hydrophilicity (swelling degree), mechanical properties (puncture testing), drug release profile (UV–VIS), and gas permeability (oxygen and carbon dioxide). The results demonstrate that DES incorporation modulates membrane properties. Chitosan membranes exhibited higher puncture resistance than some commercial dressings, with high drug release rates and enhanced hydrophilicity; however, they showed limited aqueous stability and lower gas permeability. PLA and CA membranes achieved more controlled swelling, with mechanical properties suitable for biomedical use, and a greater aqueous stability by comparison. The findings highlight the potential of DES-based biopolymeric membranes as sustainable wound dressing systems capable of controlled drug delivery. |
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