Publicação
Polyurethane – poly(ethylene glycol) hydrogels for tissue engineering applications
| Resumo: | Hydrogels are one of the most common types of biomaterials in tissue engineering and regenerative medicine. In wound healing, their use has provided access to dressings that promote a faster and more effective healing, although no single dressing is able to be used in all wounds. This work aimed at characterizing different polyurethane and poly(ethylene glycol) (PU-PEG) co-polymer hydrogel formulations and evaluating their potential as a material for wound healing. The study of the mechanical properties of hydrogels revealed a wide range of hydrogel strengths through the different formulations. Whilst no degradation was recorded in any hydrogel, their swelling profiles evidenced varied water intake within the formulations with the 12% (w/v) DABCO PU-PEG hydrogel, presenting the highest swelling ratio. Cytotoxicity assays using the L929 fibroblast cell line highlighted the hydrogels’ biocompatibility. Nonfouling studies examining protein adsorption and cellular adhesion indicated that these hydrogels display a nonfouling character that is comparable to Poly(dimethylsiloxane) across all of the hydrogel formulations examined from 15% (w/v) DABCO PU-PEG to 46% (w/v) DABCO PU-PEG. The biocompatibility of the PU-PEG hydrogels allied with mechanical properties and swelling behavior are ideal characteristics for wound dressings, as they are not only malleable and resistant to a series of strains, compatible with other materials studied for wound healing, but are also capable of exudate removal or hydration of the wound environment, promoting its healing. Furthermore, due to its nonfouling properties, a potential indication of anti-foreign body response characteristics, a desirable characteristic of biomaterials, was unveiled. Overall, valuable characterization of the various synthesized PU-PEG hydrogels, highlighted their utility in various applications across the tissue engineering field, especially in wound healing. |
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| Autores principais: | Correia, Inês Isabel Pereira |
| Assunto: | Polyurethane Poly(ethylene glycol) PU-PEG hydrogels Wound healing Nonfouling Tissue engineering |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | Hydrogels are one of the most common types of biomaterials in tissue engineering and regenerative medicine. In wound healing, their use has provided access to dressings that promote a faster and more effective healing, although no single dressing is able to be used in all wounds. This work aimed at characterizing different polyurethane and poly(ethylene glycol) (PU-PEG) co-polymer hydrogel formulations and evaluating their potential as a material for wound healing. The study of the mechanical properties of hydrogels revealed a wide range of hydrogel strengths through the different formulations. Whilst no degradation was recorded in any hydrogel, their swelling profiles evidenced varied water intake within the formulations with the 12% (w/v) DABCO PU-PEG hydrogel, presenting the highest swelling ratio. Cytotoxicity assays using the L929 fibroblast cell line highlighted the hydrogels’ biocompatibility. Nonfouling studies examining protein adsorption and cellular adhesion indicated that these hydrogels display a nonfouling character that is comparable to Poly(dimethylsiloxane) across all of the hydrogel formulations examined from 15% (w/v) DABCO PU-PEG to 46% (w/v) DABCO PU-PEG. The biocompatibility of the PU-PEG hydrogels allied with mechanical properties and swelling behavior are ideal characteristics for wound dressings, as they are not only malleable and resistant to a series of strains, compatible with other materials studied for wound healing, but are also capable of exudate removal or hydration of the wound environment, promoting its healing. Furthermore, due to its nonfouling properties, a potential indication of anti-foreign body response characteristics, a desirable characteristic of biomaterials, was unveiled. Overall, valuable characterization of the various synthesized PU-PEG hydrogels, highlighted their utility in various applications across the tissue engineering field, especially in wound healing. |
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