Publicação
Three New Labdanes Isolated from Eragrostis viscosa
| Resumo: | Three new labdanes with 8 alpha,15-epoxy ring {[}methyl 8 alpha,15-epoxylabdan-16 beta-oate, 8 alpha,15-epoxylabdan-16 beta-ol and 8 alpha,15-epoxy-16-norlabdan-13 beta-ol] and five known compounds {[}8 alpha,15-epoxy-16-norlabdan-13-one, 8 alpha,15-epoxylabdan-16 beta-oic acid, 3 beta-(3 `',4 `'-dihydroxy)-(E)-cinnamoyloxylup-20(29)-ene, 3-(2',3' 4',6'-tetra-O-acetyl-beta-D-glucopyranosyloxy)-beta-sitosterol and 16-acetoxy-8 alpha,15-epoxylabdane] were isolated from toluene and dichloromethane extracts of aerial parts of Eragrostis viscosa. The structures of all the compounds were established based on their spectroscopic data and X-ray diffraction analysis of 8 alpha,15-epoxylabdan-16 beta-ol. It was also studied the genotoxicity of E. viscosa, particularly compounds 16-acetoxy-8 alpha,15-epoxylabdane, 8 alpha,15-epoxy-16-norlabdan-13-one and 8 alpha,15-epoxilabdan-16 beta-ol, using a cytokinesis-block micronucleus assay and the Ames test to assess mutagenicity. Both assays were negative. Cytotoxicity was also analyzed using an MTT assay, and 8 alpha,15-epoxy-16 beta-ol was shown to be the most cytotoxic of the compounds tested. E. viscosa extracts were also tested to determine their antioxidant capacities, peroxide values and total phenolic contents.}} |
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| Autores principais: | Gaspar, Jorge F. |
| Outros Autores: | Martins, Célia; Rueff, José; Rueff, Jose |
| Assunto: | genotoxicity Eragrostis viscosa mutagenic activity HUMAN-LYMPHOCYTES NUTRITIVE-VALUE cytotoxic activity CURVULA 8 alpha,15-epoxylabdanes MICRONUCLEUS ASSAY ANTIOXIDANT |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | Three new labdanes with 8 alpha,15-epoxy ring {[}methyl 8 alpha,15-epoxylabdan-16 beta-oate, 8 alpha,15-epoxylabdan-16 beta-ol and 8 alpha,15-epoxy-16-norlabdan-13 beta-ol] and five known compounds {[}8 alpha,15-epoxy-16-norlabdan-13-one, 8 alpha,15-epoxylabdan-16 beta-oic acid, 3 beta-(3 `',4 `'-dihydroxy)-(E)-cinnamoyloxylup-20(29)-ene, 3-(2',3' 4',6'-tetra-O-acetyl-beta-D-glucopyranosyloxy)-beta-sitosterol and 16-acetoxy-8 alpha,15-epoxylabdane] were isolated from toluene and dichloromethane extracts of aerial parts of Eragrostis viscosa. The structures of all the compounds were established based on their spectroscopic data and X-ray diffraction analysis of 8 alpha,15-epoxylabdan-16 beta-ol. It was also studied the genotoxicity of E. viscosa, particularly compounds 16-acetoxy-8 alpha,15-epoxylabdane, 8 alpha,15-epoxy-16-norlabdan-13-one and 8 alpha,15-epoxilabdan-16 beta-ol, using a cytokinesis-block micronucleus assay and the Ames test to assess mutagenicity. Both assays were negative. Cytotoxicity was also analyzed using an MTT assay, and 8 alpha,15-epoxy-16 beta-ol was shown to be the most cytotoxic of the compounds tested. E. viscosa extracts were also tested to determine their antioxidant capacities, peroxide values and total phenolic contents.}} |
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