Publicação
Ionic-liquid-based electroactive polymer composites for muscle tissue engineering
| Resumo: | As an electromechanically active tissue, muscle regeneration takes advantage of active scaffolds providing mechanoelectrical stimuli, providing a biomimetic microenvironment. In this context, this work reports on the preparation of ionic electroactive materials based on ionic liquids (ILs) and poly(vinilidene fluoride) (PVDF). IL/PVDF composites with 10, 20 and 40\% wt. of 1-butyl-3-methylimidazolium chloride [Bmim][Cl] and 2-hydroxyethyl-trimethylammonium dihydrogenphosphate [Ch][DHP] were prepared by solvent casting. It is shown that the incorporation of [Bmim][Cl] and [Ch][DHP] not only improves the electrical conductivity but also induces the crystallization of PVDF in the polar β-phase. Further, the introduction of [Bmim][Cl] and of [Ch][DHP], respectively, decrease and increase the thermal stability of the composites. [Bmim][Cl]/PVDF composites show larger Young modulus as well as a larger increase in electrical conductivity with increasing IL content than the [Ch][DHP] ones. It is also shown that [Bmim][Cl] composites show piezoresistive response, with Gauge Factors from 1 to 2.5, allowing therefore to work as electromechanical sensors in biomechanical applications. The non-cytotoxicity of the IL/PVDF composite films and C2C12 cell proliferation demonstrates the applicability of the composites as suitable platform for muscle regeneration strategies. |
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| Autores principais: | Meira, R. M. |
| Outros Autores: | Correia, Daniela M.; Ribeiro, Sylvie; Costa, Pedro; Gomes, Andreia C; Gama, F. M.; Lanceros-Méndez, S.; Ribeiro, Clarisse |
| Assunto: | Electroactive Ionic liquid PVDF Smart materials Tissue engineering Ciências Médicas::Biotecnologia Médica |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | As an electromechanically active tissue, muscle regeneration takes advantage of active scaffolds providing mechanoelectrical stimuli, providing a biomimetic microenvironment. In this context, this work reports on the preparation of ionic electroactive materials based on ionic liquids (ILs) and poly(vinilidene fluoride) (PVDF). IL/PVDF composites with 10, 20 and 40\% wt. of 1-butyl-3-methylimidazolium chloride [Bmim][Cl] and 2-hydroxyethyl-trimethylammonium dihydrogenphosphate [Ch][DHP] were prepared by solvent casting. It is shown that the incorporation of [Bmim][Cl] and [Ch][DHP] not only improves the electrical conductivity but also induces the crystallization of PVDF in the polar β-phase. Further, the introduction of [Bmim][Cl] and of [Ch][DHP], respectively, decrease and increase the thermal stability of the composites. [Bmim][Cl]/PVDF composites show larger Young modulus as well as a larger increase in electrical conductivity with increasing IL content than the [Ch][DHP] ones. It is also shown that [Bmim][Cl] composites show piezoresistive response, with Gauge Factors from 1 to 2.5, allowing therefore to work as electromechanical sensors in biomechanical applications. The non-cytotoxicity of the IL/PVDF composite films and C2C12 cell proliferation demonstrates the applicability of the composites as suitable platform for muscle regeneration strategies. |
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