Publicação
Protein-based nanoformulations for α-Tocopherol encapsulation
| Resumo: | Nanoparticles of bovine serum albumin (BSA) and silk fibroin (SF) with entrapped α-tocopherol were produced via ultrasonic emulsification. Populations with particle size of 200300 nm and highly negatively charged were obtained for all the tested formulations. Entrapment efficiencies of around 99% revealed the effective encapsulation of α-tocopherol into the produced nanoformulations. Generally, these nanodevices did not induce significant cytotoxicity to human skin keratinocytes for all the concentrations tested. The developed formulations showed free radical scavenging of ABTS.+ ability resulting from the synergistic effect between proteins in formulation and the entrapped tocopherol. Overall, the results contribute for the establishment of BSA:VO and BSA:SF:VO as biodegradable and non-toxic nanoformulations for the functionalization of textile devices and controlled delivery of tocopherol into the skin. |
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| Autores principais: | Ghaheh, Fatemeh Shahmoradi |
| Outros Autores: | Khoddami, Akbar; Alihosseini, Farzaneh; Gomes, Andreia C; Ribeiro, Artur; Cavaco-Paulo, Artur; Silva, Carla Manuela Pereira Marinho |
| Assunto: | α-tocopherol Anti-oxidant activity Protein-based nanoparticles Skin treatment Ultrasounds |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Nanoparticles of bovine serum albumin (BSA) and silk fibroin (SF) with entrapped α-tocopherol were produced via ultrasonic emulsification. Populations with particle size of 200300 nm and highly negatively charged were obtained for all the tested formulations. Entrapment efficiencies of around 99% revealed the effective encapsulation of α-tocopherol into the produced nanoformulations. Generally, these nanodevices did not induce significant cytotoxicity to human skin keratinocytes for all the concentrations tested. The developed formulations showed free radical scavenging of ABTS.+ ability resulting from the synergistic effect between proteins in formulation and the entrapped tocopherol. Overall, the results contribute for the establishment of BSA:VO and BSA:SF:VO as biodegradable and non-toxic nanoformulations for the functionalization of textile devices and controlled delivery of tocopherol into the skin. |
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