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Designing silk-based 3D architectures with controlled lamellar morphology

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Detalhes bibliográficos
Resumo:[Excerpt] The impressive mechanical properties, along with established biocompatibility and slow degradability, render silk as an interesting biomaterial for bone tissue engineering applications. New silk-based scaffolds resembling bone lamellar structure were successfully developed using a freeze-drying technique. The structure could be controlled directly by the solute concentration and freezing parameters. The lamellar scaffolds disclosed a controlled and regular morphology (lamellar thickness: µ3.5 mm; interlamelar distance: µ15 mm). In order to induce water stability, different posttreatments were studied including methanol treatment, water annealing and steam sterilization. [...]
Autores principais:Oliveira, A. L.
Outros Autores:Sun, L.; Kim, H. J.; Hu, X.; Rice, W.; Kluge, J.; Reis, R. L.; Kaplan, D. L.
Ano:2008
País:Portugal
Tipo de documento:outro
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:[Excerpt] The impressive mechanical properties, along with established biocompatibility and slow degradability, render silk as an interesting biomaterial for bone tissue engineering applications. New silk-based scaffolds resembling bone lamellar structure were successfully developed using a freeze-drying technique. The structure could be controlled directly by the solute concentration and freezing parameters. The lamellar scaffolds disclosed a controlled and regular morphology (lamellar thickness: µ3.5 mm; interlamelar distance: µ15 mm). In order to induce water stability, different posttreatments were studied including methanol treatment, water annealing and steam sterilization. [...]

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