Publicação
Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride)
| Resumo: | Cell supports based on electroactive materials, that generate electrical signal variations as a response to mechanical deformations and vice-versa, are gaining increasing attention for tissue engineering applications. In particular, poly(vinylidene fluoride), PVDF, has been proven to be suitable for these applications in the form of films and two-dimensional membranes. In this work, several strategies have been implemented in order to develop PVDF three-dimensional scaffolds. Three processing methods, including solvent casting with particulate leaching and three- dimensional nylon, and freeze extraction with poly(vinyl alcohol) templates are presented in order to obtain three-dimensional scaffolds with different architectures and interconnected porosity. Further, it is shown that the scaffolds are in the electroactive β-phase and show a crystallinity degree of ~ 45 %. Finally, quasi-static mechanical measurements showed that an increase of the porous size within the scaffold leads to a tensile strengths and the Young’s modulus decrease, allowing tuning scaffold properties for specific tissues. |
|---|---|
| Autores principais: | Correia, D. M. |
| Outros Autores: | Ribeiro, C.; Sencadas, V.; Vikingsson, L.; Gasch, M. Oliver; Ribelles, J. L. Gómez; Botelho, Gabriela; Lanceros-Méndez, S. |
| Assunto: | Poly(vinylidene fluoride) Scaffolds Tissue engineering Mechanical properties Piezoelectric Poly(vinylidene fluoride) Ciências Naturais::Ciências Físicas |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Cell supports based on electroactive materials, that generate electrical signal variations as a response to mechanical deformations and vice-versa, are gaining increasing attention for tissue engineering applications. In particular, poly(vinylidene fluoride), PVDF, has been proven to be suitable for these applications in the form of films and two-dimensional membranes. In this work, several strategies have been implemented in order to develop PVDF three-dimensional scaffolds. Three processing methods, including solvent casting with particulate leaching and three- dimensional nylon, and freeze extraction with poly(vinyl alcohol) templates are presented in order to obtain three-dimensional scaffolds with different architectures and interconnected porosity. Further, it is shown that the scaffolds are in the electroactive β-phase and show a crystallinity degree of ~ 45 %. Finally, quasi-static mechanical measurements showed that an increase of the porous size within the scaffold leads to a tensile strengths and the Young’s modulus decrease, allowing tuning scaffold properties for specific tissues. |
|---|
Atividades financiadas
Não foram encontrados projetos financiados.