Publicação
Polydimethylsiloxane surface modification for microfluidic devices and organ-on-chip platforms
| Resumo: | One of the most popular materials for creating bio models and microfluidic devices is polydimethylsiloxane (PDMS). Recently, a unique class of devices called organs-on-a-chip (OoC) was created by fusing cell cultures with microfluidic devices. To make it easier to investigate both healthy and pathological conditions, these devices replicate the micro physiological characteristics of the human body. OoCs are most manufactured using PDMS because of its mechanical, chemical, and biocompatible qualities. However, the hydrophobic characteristics of PDMS results in several disadvantages, such as increased flow resistance, nonspecific molecular adhesion, and reduced biochemical test specificity. Additionally, because of the greater flow resistance imposed by the hydrophobicity of the microchannel walls, external flow control methods, like syringe pumps are needed in both OoC and microfluidic devices. Applying oxygen and air plasma treatment to the surface is the most often used method of increasing the PDMS surface wettability. The current study provides an insight regarding the duration and efficacy of different surface methods for PDMS surface modification: oxygen, air, and argon plasma, ultra-violet-Ozone treatment and oxygen plasma followed by immersion in polyethylene glycol, Pluronic F-127, and polyethylene oxide. |
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| Autores principais: | Gonçalves, Inês Maia Silva Rodrigo |
| Outros Autores: | Gonçalves, Margarida; Pinho, Diana; Cardoso, Beatriz Dias; Sousa, Patrícia C.; Zille, Andrea; Hori, Takeshi; Moita, Ana S.; Kaji, Hirokazu; Minas, Graça; Lima, Rui Alberto Madeira Macedo |
| Assunto: | Materials application Polymers Surface analysis Surface science Surface treatment Wettability Engenharia e Tecnologia::Engenharia dos Materiais |
| Ano: | 2026 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso embargado |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | One of the most popular materials for creating bio models and microfluidic devices is polydimethylsiloxane (PDMS). Recently, a unique class of devices called organs-on-a-chip (OoC) was created by fusing cell cultures with microfluidic devices. To make it easier to investigate both healthy and pathological conditions, these devices replicate the micro physiological characteristics of the human body. OoCs are most manufactured using PDMS because of its mechanical, chemical, and biocompatible qualities. However, the hydrophobic characteristics of PDMS results in several disadvantages, such as increased flow resistance, nonspecific molecular adhesion, and reduced biochemical test specificity. Additionally, because of the greater flow resistance imposed by the hydrophobicity of the microchannel walls, external flow control methods, like syringe pumps are needed in both OoC and microfluidic devices. Applying oxygen and air plasma treatment to the surface is the most often used method of increasing the PDMS surface wettability. The current study provides an insight regarding the duration and efficacy of different surface methods for PDMS surface modification: oxygen, air, and argon plasma, ultra-violet-Ozone treatment and oxygen plasma followed by immersion in polyethylene glycol, Pluronic F-127, and polyethylene oxide. |
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