Publicação
Reinforced multifunctional gellan gum hydrogels with nanohydroxyapatite and carbon nanotubes for improved bone regeneration
| Resumo: | [Excerpt] Introduction/Objectives: Bone can heal minor damage naturally, but larger defects often lead to scar tissue or weaknesses. Hydrogels offer an injectable, biocompatible alternative to grafts, capable of delivering bioactive cues and cells to defect sites. This study aimed to develop a multifunctional biomimetic material for minimally invasive bone regeneration. Gellan gum methacrylated (GGMA) hydrogels were reinforced with carbon nanotubes (GGMA-CNT) to mimic collagen fibers, while nano-hydroxyapatite (nHAp) was synthesized in situ on the CNTs (GGMA-nHApCNT), mimicking the natural self-assembly of hydroxyapatite on collagen. [...] |
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| Autores principais: | Maia, F. Raquel |
| Outros Autores: | Casanova, César David Rodrigues; Casanova, Marta Alexandra Rodrigues; Pina, S.; Reis, R. L.; Oliveira, Joaquim M. |
| Assunto: | Subtopic: Hydrogels Topic: Biomaterials |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | [Excerpt] Introduction/Objectives: Bone can heal minor damage naturally, but larger defects often lead to scar tissue or weaknesses. Hydrogels offer an injectable, biocompatible alternative to grafts, capable of delivering bioactive cues and cells to defect sites. This study aimed to develop a multifunctional biomimetic material for minimally invasive bone regeneration. Gellan gum methacrylated (GGMA) hydrogels were reinforced with carbon nanotubes (GGMA-CNT) to mimic collagen fibers, while nano-hydroxyapatite (nHAp) was synthesized in situ on the CNTs (GGMA-nHApCNT), mimicking the natural self-assembly of hydroxyapatite on collagen. [...] |
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