Publication
An array of highly selective Fabry-Perot optical-channels for biological fluids analysis by optical absorption using white light source for illumination
| Summary: | This paper describes a laboratorial microsystem (Microlab) used to measure the concentration of biomolecules in biological fluids. Rather than just one measurement channel, it comprises 16 optical-channels that enable the measurement of the concentration of 16 different biomolecules with the same device. An array of 16 optical filters based on Fabry-Perot thin-films optical resonators has been designed. Each optical-channel is sensitive in a single wavelength with a FWHM less than 6 nm and with a peak intensity higher than 86%. The 16 optical channels array fabrication requires only 4 masks, used with different deposition time. The Microlab can easily be tuned during fabrication to analyze different biomolecules only by adjusting the deposition times without affecting the device layout. A commercially available passband optical filter with a passband wavelength in 450-650 nm is used. The Microlab requires only a white light source for illumination due to the use of selective optical filters. The quantitative measurement of uric acid in urine is demonstrated. Such a device is extremely suitable for clinical diagnosis application in clinical laboratories and at a patient’s home because of its small size, low-cost and portability. |
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| Main Authors: | Minas, Graça |
| Other Authors: | Wolffenbuttel, R. F.; Correia, J. H. |
| Subject: | Optical filter array Fabry-Perot Pptical absorption Biomolecules analysis optical absorption |
| Year: | 2006 |
| Country: | Portugal |
| Document type: | article |
| Access type: | restricted access |
| Associated institution: | Universidade do Minho |
| Language: | English |
| Origin: | RepositóriUM - Universidade do Minho |
| Summary: | This paper describes a laboratorial microsystem (Microlab) used to measure the concentration of biomolecules in biological fluids. Rather than just one measurement channel, it comprises 16 optical-channels that enable the measurement of the concentration of 16 different biomolecules with the same device. An array of 16 optical filters based on Fabry-Perot thin-films optical resonators has been designed. Each optical-channel is sensitive in a single wavelength with a FWHM less than 6 nm and with a peak intensity higher than 86%. The 16 optical channels array fabrication requires only 4 masks, used with different deposition time. The Microlab can easily be tuned during fabrication to analyze different biomolecules only by adjusting the deposition times without affecting the device layout. A commercially available passband optical filter with a passband wavelength in 450-650 nm is used. The Microlab requires only a white light source for illumination due to the use of selective optical filters. The quantitative measurement of uric acid in urine is demonstrated. Such a device is extremely suitable for clinical diagnosis application in clinical laboratories and at a patient’s home because of its small size, low-cost and portability. |
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