Detalhes bibliográficos
| Resumo: | Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds. |
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| Autores principais: | Aroso, Ivo Manuel Ascensão |
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| Outros Autores: | Craveiro, Rita; Rocha, Ângelo; Dionisio, Madalena; Barreiros, Susana; Reis, R. L.; Paiva, Alexandre; Duarte, Ana Rita C. |
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| Assunto: | Biodegradable polymers Drug delivery systems Ibuprofen Supercritical carbon dioxide Therapeutic deep eutectic solvents Ciências Médicas::Biotecnologia Médica |
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| Ano: | 2015 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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