Publication
Hand, Foot, and Mouth Syndrome in an Immunocompetent Adult: a Case Report
| Summary: | BACKGROUND: Hand, foot, and mouth syndrome (HFMS) is a common acute illness. It is characterized by mild clinical symptoms including fever, blisters, and sores in the mouth and on the palms and soles following a 3- to 7-day incubation period. This syndrome is rarely seen in adults. CASE PRESENTATION: A 35-year-old male Caucasian patient had a history of multiple episodes of acute pharyngitis, hypertension, hypercholesterolemia, and occasional abdominal pain. He presented with polyarthralgia in the knees and hands and odynophagia, followed by fever, oral mucosal aphthous lesions, and vesicles on the palms and soles. Three weeks after presentation, he was admitted to the emergency room with acute myocarditis. The in-hospital evaluation revealed positive serology for coxsackie A9 (1:160), positive anti-transglutaminase and anti-gliadin antibodies, normal immunoglobulins, and human immunodeficiency virus negativity. CONCLUSION: We herein describe a case of HFMS that was associated with coxsackie A9 infection complicated by acute myocarditis. Although an association between celiac disease and HFMS has not been described, this patient's immunologic disruption could have favored the development of infection and ultimately HFMS. |
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| Main Authors: | Flor de Lima, B |
| Other Authors: | Silva, J; Rodrigues, AC; Grilo, A; Riso, N; Vaz Riscado, M |
| Subject: | HCC INF Acute Disease Celiac Disease/complications Celiac Disease/pathology Celiac Disease/immunology Celiac Disease/virology Enterovirus B, Human/immunology Enterovirus B, Human/isolation & purification Hand, Foot and Mouth Disease/complications Hand, Foot and Mouth Disease/immunology Hand, Foot and Mouth Disease/pathology Hand, Foot and Mouth Disease/virology Immunocompetence Myocarditis/complications Myocarditis/immunology Myocarditis/pathology Myocarditis/virology |
| Year: | 2013 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Centro Hospitalar de Lisboa Central, EPE (CHLC) |
| Language: | English |
| Origin: | Repositório do Centro Hospitalar de Lisboa Central, EPE |
| Summary: | BACKGROUND: Hand, foot, and mouth syndrome (HFMS) is a common acute illness. It is characterized by mild clinical symptoms including fever, blisters, and sores in the mouth and on the palms and soles following a 3- to 7-day incubation period. This syndrome is rarely seen in adults. CASE PRESENTATION: A 35-year-old male Caucasian patient had a history of multiple episodes of acute pharyngitis, hypertension, hypercholesterolemia, and occasional abdominal pain. He presented with polyarthralgia in the knees and hands and odynophagia, followed by fever, oral mucosal aphthous lesions, and vesicles on the palms and soles. Three weeks after presentation, he was admitted to the emergency room with acute myocarditis. The in-hospital evaluation revealed positive serology for coxsackie A9 (1:160), positive anti-transglutaminase and anti-gliadin antibodies, normal immunoglobulins, and human immunodeficiency virus negativity. CONCLUSION: We herein describe a case of HFMS that was associated with coxsackie A9 infection complicated by acute myocarditis. Although an association between celiac disease and HFMS has not been described, this patient's immunologic disruption could have favored the development of infection and ultimately HFMS. |
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