Bibliographic Details
| Summary: | Introduction: Coronary vasomotion disorders (CVDs), including microvascular angina (MVA) and vasospastic angina (VSA), account for significant morbidity among patients with non-obstructive coronary artery disease (NOCAD). However, protocols for CVD assessment in clinical practice are seldom standardized and may be difficult to implement. Purpose: To assess the safety and feasibility of a comprehensive coronary function test (CFT) protocol for assessment of CVD and the prevalence of different phenotypes of CVD in patients with angina and NOCAD (ANOCA). Methods: Patients with persistent angina referred for invasive coronary angiogram and found to have NOCAD were prospectively recruited and underwent a CFT. Functional parameters (fractional flow reserve, coronary flow reserve and index of myocardial resistance) and coronary vasoreactivity were assessed in all patients. Results: Of the 20 patients included, the mean age was 63±13 years and 50% were females. Most patients had persistent typical angina and evidence of ischemia in noninvasive tests (75%). The CFT was successfully performed in all subjects without serious complications. Isolated MVA was found in 25%, isolated VSA in 40%, both MVA and VSA in 10% and noncardiac chest pain in 25% of patients. Antianginal therapy was modified after the results of CFT in 70% of patients. Conclusion: A coronary function test was feasible and safe in a cohort of patients with ANOCA. CVD were prevalent in this selected group of patients, and some presented mixed CVD phenotypes. CFT may provide a definitive diagnosis in patients with persistent angina and prompt the stratification of pharmacological therapy. |
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| Main Authors: | Vaz Ferreira, V |
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| Other Authors: | Ramos, R; Castelo, A; Mendonça, T; Almeida-Morais, L; Pereira-da-Silva, T; Oliveira, E; Viegas, J; Garcia Brás, P; Grazina, A; Cacela, D; Cruz Ferreira, R |
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| Subject: | HSM CAR Humans Female Male Coronary Angiography Coronary Artery Disease* / diagnosis Coronary Vessels Fractional Flow Reserve, Myocardial* Ischemia Microvascular Angina* / diagnosis Microvascular Angina* / epidemiology |
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| Year: | 2023 |
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| Country: | Portugal |
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| Document type: | article |
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| Access type: | open access |
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| Associated institution: | Centro Hospitalar de Lisboa Central, EPE (CHLC) |
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| Language: | English |
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| Origin: | Repositório do Centro Hospitalar de Lisboa Central, EPE |
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