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Pregnancy and multiple sclerosis: the initial results from a Brazilian database

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Detalhes bibliográficos
Resumo:PURPOSE: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject. METHOD: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies). RESULTS: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature. CONCLUSION: Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.
Autores principais:Fragoso,Yara Dadalti
Outros Autores:Finkelsztejn,Alessandro; Comini-Frota,Elizabeth Regina; Gama,Paulo Diniz da; Grzesiuk,Ansderson Kuntz; Khouri,Jussara Mathias Netto; Alves-Leon,Soniza Vieira; Morales,Rogério de Rizo; Lana-Peixoto,Marco Aurélio; Rocha,Cristiane Franklin da
Assunto:multiple sclerosis pregnancy prematurity low birth weight obstetric complications interferon beta glatiramer acetate
Ano:2009
País:Brasil
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:IBICT
Idioma:inglês
Origem:Oasisbr
Descrição
Resumo:PURPOSE: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject. METHOD: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies). RESULTS: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature. CONCLUSION: Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.

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