Detalhes bibliográficos
| Resumo: | ABSTRACT PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed. RESULTS: All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions. CONCLUSION: Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application. |
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| Autores principais: | Ohashi,Camila Melo |
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| Outros Autores: | Caldeira,Fabio Alves Morikawa; Feitosa-Junior,Denilson José Silva; Valente,André Lopes; Dutra,Paulo Roberto Witter; Miranda,Moysés dos Santos; Santos,Simone do Socorro Damasceno; Brito,Marcus Vinicius Henriques; Ohashi,Otávio Mitio; Yasojima,Edson Yuzur |
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| Assunto: | Adipose Tissue Wound Healing Stem Cells Rats |
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| Ano: | 2016 |
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| País: | Brasil |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | IBICT |
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| Idioma: | inglês |
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| Origem: | Oasisbr |
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