Publicação
Systematic review of COVID-19 associated with aspergillosis: perspectives for a new diagnosis
| Resumo: | The association of severe acute respiratory syndrome 2 (SARS-COV-2) with invasive pulmonary aspergillosis (API) is called CAPA. Clinical treatment protocols are not described in the world or national literature resulting in low efficacy and high mortality. The objective was to associate the manifestations of SARS-COV-2 and API, in relation to the diagnostic methods, pulmonary dysfunction and clinical outcome. The systematic literature review was based on Pubmed, with English descriptors: “aspergilosis”, “covid”, “histology”, boolean "and", with filters: human and published from 2019. 31 articles were identified and 10 were included. The diagnosis for API included research of the Aspergillus galactomannan antigen in serum or sputum, Aspergillus PCR in tracheal aspirate and culture of respiratory samples. The highlighted respiratory compromises are ground-glass opacities, nodular consolidations, bilateral interstitial pulmonary infiltrate, with death as one of the common outcome. CAPA is a co-infection process, future clinical trials are necessary to develop integrated diagnosis, to improve the clinical outcome and minimize mortality. |
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| Autores principais: | Gervásio, Flávia Martins |
| Outros Autores: | Franco, Jéssyka Viana Valadares; Sampaio, Andressa de Sousa; Passos, Adna Rocha dos; Sakamoto, Agnês Mie; Silva, Daniela de Sousa; Braz, Dayanna Cristina; Seixas , Geovanna Cardoso; Spindola, Letícia Antunes; Abreu , Thamires Monteiro de |
| Assunto: | Dysfunction pulmonary Diagnosis Respiratory syndrome of acute discomfort (ARDS) Fungus culture Co-infection. Alterações pulmonares Diagnóstico Síndrome respiratória do desconforto agudo (SARA) Cultura de fungos Coinfecção. Alteraciones pulmonares Diagnóstico Síndrome de dificultad respiratoria aguda (SDRA) Cultivo de hongos Coinfección. |
| Ano: | 2022 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | IBICT |
| Idioma: | português |
| Origem: | Oasisbr |
| Resumo: | The association of severe acute respiratory syndrome 2 (SARS-COV-2) with invasive pulmonary aspergillosis (API) is called CAPA. Clinical treatment protocols are not described in the world or national literature resulting in low efficacy and high mortality. The objective was to associate the manifestations of SARS-COV-2 and API, in relation to the diagnostic methods, pulmonary dysfunction and clinical outcome. The systematic literature review was based on Pubmed, with English descriptors: “aspergilosis”, “covid”, “histology”, boolean "and", with filters: human and published from 2019. 31 articles were identified and 10 were included. The diagnosis for API included research of the Aspergillus galactomannan antigen in serum or sputum, Aspergillus PCR in tracheal aspirate and culture of respiratory samples. The highlighted respiratory compromises are ground-glass opacities, nodular consolidations, bilateral interstitial pulmonary infiltrate, with death as one of the common outcome. CAPA is a co-infection process, future clinical trials are necessary to develop integrated diagnosis, to improve the clinical outcome and minimize mortality. |
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Atividades financiadas
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