Publicação

Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study

Detalhes bibliográficos
Resumo:	This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies.
Autores principais:	Carvalho Júnior,Álvaro Dutra de
Outros Autores:	Abrantes,Fabiana Moreira; Menezes,Maria Ângela; Leal,Alexandre Soares; Cardoso,Valbert Nascimento; Oliveira,Mônica Cristina de
Assunto:	Radiolabelled cisplatin biodistribution TRIGA research reactor
Ano:	2005
País:	Brasil
Tipo de documento:	artigo
Tipo de acesso:	acesso aberto
Instituição associada:	IBICT
Idioma:	inglês
Origem:	Oasisbr

Descrição
Resumo:	This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies.

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