Publicação
Sildenafil for pulmonary hypertension treatment after cardiac surgery
| Resumo: | Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In postoperative the newborn had pulmonary hypertension and persistent hypoxia, without response to nitric oxide, but with improved oxygenation after continuous intravenous infusion of prostaglandin E1. After several failed attempts to discontinue prostaglandin E1, oral sildenafil was used. There was a decrease in pulmonary vascular resistance with consequent oxygenation improvement and 48 hours later it was possible to discontinue prostaglandin E1 infusion. Comments: Sildenafil can be an alternative therapy for pulmonary hypertension, especially when there is no response to conventional therapy. Copyright © 2005 by Sociedade Brasileira de Pediatria. |
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| Autores principais: | Bentlin, Maria Regina |
| Outros Autores: | Saito, Adriana; De Luca, Ana Karina C.; Bossolan, Grasiela; Bonatto, Rossano César; Martins, Antonio Sérgio; Rugolo, Ligia Maria Suppo de Souza |
| Assunto: | Prostaglandin Pulmonary hypertension Sildenafil nitric oxide prostaglandin E1 sildenafil phosphodiesterase inhibitor piperazine derivative Blalock Taussig anastomosis cardiovascular parameters case report diagnostic procedure drug dose regimen drug mechanism female heart right ventricle double outlet heart surgery heart ventricle septum defect human hypoxia lung hypoplasia newborn oxygenation pulmonary hypertension postoperative period Cardiac Surgical Procedures Female Humans Hypertension, Pulmonary Infant, Newborn Phosphodiesterase Inhibitors Piperazines Postoperative Period |
| Ano: | 2014 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| Resumo: | Objective: To report on the use of sildenafil for pulmonary hypertension treatment of a newborn patient after cardiac surgery. Description: A female, full term newborn infant with diagnosis of double outlet right ventricle, pulmonary hypoplasia and subaortic ventricular septal defect, was submitted to Blalock surgery in the first week of life. In postoperative the newborn had pulmonary hypertension and persistent hypoxia, without response to nitric oxide, but with improved oxygenation after continuous intravenous infusion of prostaglandin E1. After several failed attempts to discontinue prostaglandin E1, oral sildenafil was used. There was a decrease in pulmonary vascular resistance with consequent oxygenation improvement and 48 hours later it was possible to discontinue prostaglandin E1 infusion. Comments: Sildenafil can be an alternative therapy for pulmonary hypertension, especially when there is no response to conventional therapy. Copyright © 2005 by Sociedade Brasileira de Pediatria. |
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