Publicação
Simultaneous differential pulse voltammetric determination of L-dopa and carbidopa in pharmaceuticals using a carbon paste electrode modified with lead dioxide immobilized in a polyester resin
| Resumo: | A carbon paste electrode modified with lead dioxide immobilized in a polyester resin has been developed for simultaneous differential pulse voltammetric determination of L-dopa and carbidopa in pharmaceutical formulations. The analytical curves were linear in the concentration ranges from 2.6 <FONT FACE=Symbol>´</FONT> 10-4 to 1.2 <FONT FACE=Symbol>´</FONT> 10-3 mol L-1 and from 3.2 <FONT FACE=Symbol>´</FONT> 10-5 to 1.5 <FONT FACE=Symbol>´</FONT> 10-4 mol L-1 for L-dopa and carbidopa, respectively. The detection limits were 2.5 <FONT FACE=Symbol>´</FONT> 10-5 mol L-1 and 3.7 <FONT FACE=Symbol>´</FONT> 10-6 mol L-1 for L-dopa and carbidopa, respectively and recoveries of L-dopa and carbidopa from two samples ranged from 98.1 to 103% of the added amount. The relative standard deviations were lower than 2.5% for 1.2 <FONT FACE=Symbol>´</FONT> 10-4 and 1.2 <FONT FACE=Symbol>´</FONT> 10-3 mol L-1 of these catecholamines solutions and the results obtained for L-dopa and carbidopa in pharmaceutical formulations using the proposed voltammetric procedure are in close agreement with the labeled values and/or those obtained using an enzymatic method at the 95% confidence level. |
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| Autores principais: | Melo,Hélio Corrêa de |
| Outros Autores: | Seleghim,Ana Paula D.; Polito,Wagner Luiz; Fatibello-Filho,Orlando; Vieira,Iolanda C. |
| Assunto: | L-dopa carbidopa differential pulse voltammetry (DPV) carbon paste electrode modified with lead dioxide |
| Ano: | 2007 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| Resumo: | A carbon paste electrode modified with lead dioxide immobilized in a polyester resin has been developed for simultaneous differential pulse voltammetric determination of L-dopa and carbidopa in pharmaceutical formulations. The analytical curves were linear in the concentration ranges from 2.6 <FONT FACE=Symbol>´</FONT> 10-4 to 1.2 <FONT FACE=Symbol>´</FONT> 10-3 mol L-1 and from 3.2 <FONT FACE=Symbol>´</FONT> 10-5 to 1.5 <FONT FACE=Symbol>´</FONT> 10-4 mol L-1 for L-dopa and carbidopa, respectively. The detection limits were 2.5 <FONT FACE=Symbol>´</FONT> 10-5 mol L-1 and 3.7 <FONT FACE=Symbol>´</FONT> 10-6 mol L-1 for L-dopa and carbidopa, respectively and recoveries of L-dopa and carbidopa from two samples ranged from 98.1 to 103% of the added amount. The relative standard deviations were lower than 2.5% for 1.2 <FONT FACE=Symbol>´</FONT> 10-4 and 1.2 <FONT FACE=Symbol>´</FONT> 10-3 mol L-1 of these catecholamines solutions and the results obtained for L-dopa and carbidopa in pharmaceutical formulations using the proposed voltammetric procedure are in close agreement with the labeled values and/or those obtained using an enzymatic method at the 95% confidence level. |
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