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Antinociceptive action of Light Emitting Diode in an experimental model with hyperalgesia by capsaicin

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Bibliographic Details
Summary:OBJECTIVE: To assess the antinociceptive effect of a light emitting diode (LED) in the acute phase of pain induced by capsaicin. METHOD: Twelve Wistar rats were used, divided into a control and an experimental group. The pain process was induced in both groups by applying 50 microliters of a 2% capsaicin solution in the plantar region of the right hind limb. In the experimental group, a single application of LED 627nm (70mw, 7 Joules/cm2 dose) was also applied. Nociception was assessed 30 minutes and 24 hours after LED application using a digital analgesymeter (Von Frey). RESULTS: Twenty four hours after irradiation, an increase in the nociceptive threshold was observed in the LED group in comparison to the 30 min level, as well as in the inter-group comparison. CONCLUSIONS: The use of LED can be considered as a non-invasive analgesic method as it increases of the nociceptive threshold 24 hours after pain is induced.
Main Authors:Kerppers,Ivo Ilvan
Other Authors:Paz,Isabel de Almeida; Pires,Juliana Aparecida Wosch; Ribeiro,Larissa Gulogurski; Rolão,Marcos Paulo Polowei; Furmann,Meiriélly; Oliveira,Thais Barbosa de; Eltchechem,Camila da Luz; Pereira,Mario César da Silva; Fréz,Andersom Ricardo
Subject:Light Emitting Diode nociception pain measurement
Year:2014
Country:Brazil
Document type:article
Access type:open access
Associated institution:IBICT
Language:English
Origin:Oasisbr
Description
Summary:OBJECTIVE: To assess the antinociceptive effect of a light emitting diode (LED) in the acute phase of pain induced by capsaicin. METHOD: Twelve Wistar rats were used, divided into a control and an experimental group. The pain process was induced in both groups by applying 50 microliters of a 2% capsaicin solution in the plantar region of the right hind limb. In the experimental group, a single application of LED 627nm (70mw, 7 Joules/cm2 dose) was also applied. Nociception was assessed 30 minutes and 24 hours after LED application using a digital analgesymeter (Von Frey). RESULTS: Twenty four hours after irradiation, an increase in the nociceptive threshold was observed in the LED group in comparison to the 30 min level, as well as in the inter-group comparison. CONCLUSIONS: The use of LED can be considered as a non-invasive analgesic method as it increases of the nociceptive threshold 24 hours after pain is induced.

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