Publicação

Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives

Detalhes bibliográficos
Resumo:	In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 μM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 μM.
Autores principais:	Jin, Qing-Hao
Outros Autores:	Fu, Zhi-Yang; Xia, Ya-Nan; Liu, Bing-Yu; Jiang, Hai-Ying
Assunto:	Flavonoids Synthesis Isoprenyloxyflavones Antibacterial activity
Ano:	2020
País:	Brasil
Tipo de documento:	artigo
Tipo de acesso:	unknown
Instituição associada:	IBICT
Idioma:	inglês
Origem:	Oasisbr

Descrição
Resumo:	In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 μM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 μM.

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