Publication
Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
| Summary: | Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess. |
|---|---|
| Main Authors: | Lopes,Raquel O. |
| Other Authors: | Grimm,Simon; Ribeiro,Joyce B.; Leal,Ivana C. R.; Miranda,Leandro S. M.; Souza,Rodrigo O. M. A. de |
| Subject: | whole cell bioreduction packed bed reactor continuous flow asymmetric reduction |
| Year: | 2015 |
| Country: | Brazil |
| Document type: | article |
| Access type: | open access |
| Associated institution: | IBICT |
| Language: | English |
| Origin: | Oasisbr |
| Summary: | Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess. |
|---|
Funded activities
No funded projects found.