Bibliographic Details
| Summary: | Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins. |
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| Main Authors: | Martins,Darliane A. |
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| Other Authors: | Bomfim Filho,Lucius F.; Silva,Cleiton M. da; Fátima,Ângelo de; Louro,Sonia R. W.; Batista,Denise G. J.; Soeiro,Maria de Nazaré C.; Carvalho,João Ernesto de; Teixeira,Letícia R. |
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| Subject: | Schiff base copper(II) complexes biological activity DNA albumin |
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| Year: | 2017 |
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| Country: | Brazil |
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| Document type: | article |
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| Access type: | open access |
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| Associated institution: | IBICT |
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| Language: | English |
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| Origin: | Oasisbr |
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