Publicação
Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
| Resumo: | Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
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| Autores principais: | Siqueira,Lilian |
| Outros Autores: | Paula,Cynthia Guimarães de; Motisuke,Mariana; Gouveia,Rubia Figueredo; Camargo,Samira Esteves Afonso; Milhan,Noala Vicensoto Moreira; Trichês,Eliandra de Sousa |
| Assunto: | Tricalcium phosphate alumina gel-casting method cytocompatibility scaffolds |
| Ano: | 2017 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| Resumo: | Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
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