Publication
Sulfadiazine determination in pharmaceuticals by electrochemical reduction on a glassy carbon electrode
| Summary: | Sulfadiazine was quantified in two samples of pharmaceutical preparations by square-wave voltammetry. The analytical signal response was obtained by electrochemical reduction instead of oxidation of the sulfa drug at a glassy carbon electrode. The determination was carried out in 0.04 mol L-1 Britton-Robinson pH 6.8 buffer solution. Sulfadiazine reduction was observed at -1.49 V vs. Ag/AgCl in one well-resolved irreversible peak. The analytical curve was obtained in the concentration range of 62.7 to 340 µmol L-1 (r = 0.9986) with a detection limit of 10.9 µmol L-1. For one sample analyzed, recovery values were in the range of 94.9 to 101.1%, while for the other sample they were within 96.0 to 104.6%, indicating no matrix interference effects on the analytical results for both sulfadiazine samples. The accuracy of the electroanalytical method was compared to the standard amperometric titration method. |
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| Main Authors: | Braga,Otoniel C. |
| Other Authors: | Campestrini,Iolana; Vieira,Iolanda C.; Spinelli,Almir |
| Subject: | sulfadiazine pharmaceuticals electrochemical reduction square-wave voltammetry glassy carbon electrode |
| Year: | 2010 |
| Country: | Brazil |
| Document type: | article |
| Access type: | open access |
| Associated institution: | IBICT |
| Language: | English |
| Origin: | Oasisbr |
| Summary: | Sulfadiazine was quantified in two samples of pharmaceutical preparations by square-wave voltammetry. The analytical signal response was obtained by electrochemical reduction instead of oxidation of the sulfa drug at a glassy carbon electrode. The determination was carried out in 0.04 mol L-1 Britton-Robinson pH 6.8 buffer solution. Sulfadiazine reduction was observed at -1.49 V vs. Ag/AgCl in one well-resolved irreversible peak. The analytical curve was obtained in the concentration range of 62.7 to 340 µmol L-1 (r = 0.9986) with a detection limit of 10.9 µmol L-1. For one sample analyzed, recovery values were in the range of 94.9 to 101.1%, while for the other sample they were within 96.0 to 104.6%, indicating no matrix interference effects on the analytical results for both sulfadiazine samples. The accuracy of the electroanalytical method was compared to the standard amperometric titration method. |
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