Detalhes bibliográficos
| Resumo: | The aim of this study was to investigate the cytotoxic activity and inhibitory effect of terpinen-4-ol (T4ol) and carvacrol against single- and multi-species biofilms. The toxicity of each compound was tested on oral keratinocytes and evaluated by XTT assay. Inhibition and eradication of single-species biofilms were analyzed by crystal violet assay and the effect on multi-species biofilm composition was evaluated by qPCR. T4ol and carvacrol did not affect the epithelial cell viability, in contrast to chlorhexidine, which showed a high cytotoxic effect. Inhibition and eradication of single-species biofilms treated with T4ol and carvacrol were observed. The same inhibitory effect was observed for multi-species biofilms, especially on periodontal pathogens. In conclusion, specific concentrations of T4ol and carvacrol without toxicity towards the epithelial cells reduced the numbers of periodontal pathogens in single- and multi-species biofilms. |
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| Autores principais: | Maquera Huacho, Patricia Milagros |
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| Outros Autores: | Rodriguez Herrero, Esteban; Verspecht, Tim; Pauwels, Martine; Marcantonio, Elcio; Palomari Spolidorio, Denise Madalena; Teughels, Wim |
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| Assunto: | carvacrol multi-species biofilm peri-implantitis periodontal disease Terpinen-4-ol |
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| Ano: | 2019 |
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| País: | Brasil |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | IBICT |
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| Idioma: | inglês |
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| Origem: | Oasisbr |
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