Publicação
Effects of depomedroxyprogesterone acetate on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats (Rattus norvegicus)
| Resumo: | The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA) on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG), which received injections of sterile saline; positive control groups (PCG), which were given injections of estradiol valerate; and progesterone groups (PG), which were given injections of Depo-Provera®. After one week of hormonal induction, vaginal infection by C. albicans was induced in all the groups and detected by vaginal yeast culture and Papanicolaou smear. In addition, scanning and transmission electron microscopy images were obtained to confirm the vaginal infection by yeast in PG. A difference in progesterone levels in PG was observed between the basal level and after hormonal induction (P |
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| Autores principais: | Storti-Filho, Agenor |
| Outros Autores: | Damke, Edilson; Carrara, Márcia Aparecida; Batista, Marcia Regina; Donatti, Lucélia; Boer, Cinthia Gandolfi; Svizdinski, Terezinha Inez Estivalet; Consolaro, Márcia Edilaine Lopes |
| Assunto: | Acetato de depomedroxyprogesterona^i2^sefei Acetato de depomedroxyprogesterona^i2^sestudo experimen Candidiase vulvovaginal Candida albicans Depomedroxyprogesterone acetate^i1^seffe Depomedroxyprogesterone acetate^i1^sexperimental st Vulvovaginal candidiasis Candida albicans |
| Ano: | 2011 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| Resumo: | The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA) on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG), which received injections of sterile saline; positive control groups (PCG), which were given injections of estradiol valerate; and progesterone groups (PG), which were given injections of Depo-Provera®. After one week of hormonal induction, vaginal infection by C. albicans was induced in all the groups and detected by vaginal yeast culture and Papanicolaou smear. In addition, scanning and transmission electron microscopy images were obtained to confirm the vaginal infection by yeast in PG. A difference in progesterone levels in PG was observed between the basal level and after hormonal induction (P |
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