Publicação
The prodrug approach: A successful tool for improving drug solubility
| Resumo: | Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years. |
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| Autores principais: | Jornada, Daniela Hartmann |
| Outros Autores: | Dos Santos Fernandes, Guilherme Felipe; Chiba, Diego Eidy; De Melo, Thais Regina Ferreira; Dos Santos, Jean Leandro; Chung, Man Chin |
| Assunto: | Molecular modification Prodrug Solubility Solubility of prodrugs Water-soluble prodrugs |
| Ano: | 2018 |
| País: | Brasil |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| Resumo: | Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years. |
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