Publicação

Structure development during additive manufacturing

Detalhes bibliográficos
Resumo:	Additive manufacturing involves the shaping of a product through the use of a liquid phase which is subsequently transformed to the solid state by cooling or through the use of chemical cross-linking reactions. Of particular note is the fused deposition modeling which utilizes semi-crystalline polymers such as poly(ε-caprolactone) or poly(lactic acid) and has been employed in CDRsp to prepare highly porous scaffolds for Tissue Engineering. We show that the crystallization process amplifies small levels of molecular anisotropy introduced in the additive writing process. We show that the level of anisotropy is significantly dependent on the process parameters such as temperature, write speed, and flow rate. The differences in the crystalline morphology introduced by changing these process parameters will have a marked impact on the mechanical properties. This in turn will alter the growth of tissue on such scaffold structures. As with other polymer processing procedures, tuning the process parameters provides a route to controlling and defining the structure and morphology of the scaffold and the properties exhibited by that scaffold.
Autores principais:	Tojeira, A.
Outros Autores:	Biscaia, S.; Viana, T.; Bártolo, P. J.; Mitchell, G. R.
Assunto:	3D printers Anisotropy Crosslinking Manufacture Mechanical properties Rapid prototyping Scaffolds (biology)
Ano:	2013
País:	Portugal
Tipo de documento:	comunicação em conferência
Tipo de acesso:	acesso restrito
Instituição associada:	Universidade de Leiria e Oeste
Idioma:	inglês
Origem:	IC-online

Descrição
Resumo:	Additive manufacturing involves the shaping of a product through the use of a liquid phase which is subsequently transformed to the solid state by cooling or through the use of chemical cross-linking reactions. Of particular note is the fused deposition modeling which utilizes semi-crystalline polymers such as poly(ε-caprolactone) or poly(lactic acid) and has been employed in CDRsp to prepare highly porous scaffolds for Tissue Engineering. We show that the crystallization process amplifies small levels of molecular anisotropy introduced in the additive writing process. We show that the level of anisotropy is significantly dependent on the process parameters such as temperature, write speed, and flow rate. The differences in the crystalline morphology introduced by changing these process parameters will have a marked impact on the mechanical properties. This in turn will alter the growth of tissue on such scaffold structures. As with other polymer processing procedures, tuning the process parameters provides a route to controlling and defining the structure and morphology of the scaffold and the properties exhibited by that scaffold.

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