Publicação
Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate
| Resumo: | Sugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hydroxyethyl methacrylate (HEMA) and SucMA in a 70:30 ethylene glycol/water mixed solvent using ammonium persulphate/sodium methabisulphite pair as initiating system. The swelling behaviour of these gels was evaluated as a function of crosslinker content, copolymer composition, pH and ionic strength. In addition, the diffusional behaviour of sodium salycilate (SSA) from these gels and poly(HEMA) gels is also reported. |
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| Autores principais: | Ferreira, L. |
| Outros Autores: | Vidal, M. M.; Geraldes, C. F. G. C.; Gil, M. H. |
| Assunto: | Sucrose Glycidyl methacrylate Swelling Drug release |
| Ano: | 2000 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | inglês |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | Sugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hydroxyethyl methacrylate (HEMA) and SucMA in a 70:30 ethylene glycol/water mixed solvent using ammonium persulphate/sodium methabisulphite pair as initiating system. The swelling behaviour of these gels was evaluated as a function of crosslinker content, copolymer composition, pH and ionic strength. In addition, the diffusional behaviour of sodium salycilate (SSA) from these gels and poly(HEMA) gels is also reported. |
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