Publicação
Sustained drug released from contact lens
| Resumo: | This paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days. |
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| Autores principais: | Ferreira, J. A. |
| Outros Autores: | Oliveira, P. de; Silva, P. M. da; Carreira, A.; Gil, H.; Murta, J. N. |
| Assunto: | Ophthalmic drug delivery Contact lenses p-(HEMA/MAA) Reaction-diffusion equation Qualitative behaviour Numerical simulation Experimental results |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | preprint |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | inglês |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | This paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days. |
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