Detalhes bibliográficos
| Resumo: | A series of easily obtained pyrrolidine-based [beta]-amino alcohols derived from tartaric acid and primary amines was synthesized and used as chiral ligands in the enantioselective alkylation of benzaldehyde. Using diethylzinc, 1-phenyl-1-propanol was obtained with enantiomeric excesses of up to 80% when (3S,4S)-N-(1-naphthylmethyl)-3,4-dihydroxypyrrolidine was used. The nature of the N-substituent on the ligand, as well as the reaction temperature proved to significantly influence reaction product distribution as well as the enantiomeric excess of the chiral alcohol. |
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| Autores principais: | Gonsalves, António M. d'. A. Rocha |
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| Outros Autores: | Serra, M. Elisa S.; Murtinho, Dina; Silva, Vitor F.; Beja, A. Matos; Paixão, J. A.; Silva, M. Ramos; Veiga, L. Alte da |
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| Assunto: | Enantioselective alkylation [beta]-Amino alcohols Diethylzinc Pyrrolidinoalcohols Benzaldehyde |
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| Ano: | 2003 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade de Coimbra |
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| Idioma: | inglês |
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| Origem: | Estudo Geral - Universidade de Coimbra |
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