Publicação
Internship Reports and Monograph entitled “ “Circadian Rhythm Disruption and Female Fertility”
| Resumo: | The circadian rhythm is a 24-hour endogenous cycle generated by molecular clocks that coordinate vital physiological processes. These rhythms are coordinated by a central pacemaker, which is in the suprachiasmatic nucleus, and several peripheral clocks that are distributed throughout the body. The circadian system plays a crucial role in regulating biological processes, including those related to reproduction. In women, synchronization between circadian rhythms and the hypothalamic-pituitary-ovarian axis is essential for folliculogenesis, ovulation, implantation and pregnancy success. In turn, disruption of the circadian rhythmicity as observed in shift work and sleep disorders, has been associated with multiple mechanisms that can compromise reproductive outcomes and fertility, including hormonal, metabolic and immune dysregulation.Increasing evidence has demonstrated that melatonin plays a central role in women’s reproductive success due to its antioxidant and endocrine regulatory properties. Therefore, therapeutic interventions may include melatonin supplementation or other circadian modulators, which aim to restore the circadian rhythm and mitigate the adverse effects of circadian disruption on fertility.Despite strong experimental evidence in animal models, the transposition to humans remains limited. While current studies suggest an association between dysregulation and infertility, many clinical findings remain inconclusive. This underscores a critical gap: a lack of large-scale, controlled clinical studies capable of clarifying causal relationships and therapeutic potential. Additionally, while chronotherapy and chronobiotics have the potential to enhance fertility outcomes, their incorporation into reproductive medicine is still in its infancy.This monograph reviews the relationship between circadian disruption and impaired female fertility, while presenting strategies targeting the circadian system in order to reduce misalignment and optimize reproductive outcomes. |
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| Autores principais: | Faim, Beatriz Varanda |
| Assunto: | Circadian rhythm Reproduction Circadian rhythm disruption Female fertility Melatonin Ritmo circadiano Reprodução Disrupção do ritmo circadiano Fertilidade feminina Melatonina |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | inglês |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | The circadian rhythm is a 24-hour endogenous cycle generated by molecular clocks that coordinate vital physiological processes. These rhythms are coordinated by a central pacemaker, which is in the suprachiasmatic nucleus, and several peripheral clocks that are distributed throughout the body. The circadian system plays a crucial role in regulating biological processes, including those related to reproduction. In women, synchronization between circadian rhythms and the hypothalamic-pituitary-ovarian axis is essential for folliculogenesis, ovulation, implantation and pregnancy success. In turn, disruption of the circadian rhythmicity as observed in shift work and sleep disorders, has been associated with multiple mechanisms that can compromise reproductive outcomes and fertility, including hormonal, metabolic and immune dysregulation.Increasing evidence has demonstrated that melatonin plays a central role in women’s reproductive success due to its antioxidant and endocrine regulatory properties. Therefore, therapeutic interventions may include melatonin supplementation or other circadian modulators, which aim to restore the circadian rhythm and mitigate the adverse effects of circadian disruption on fertility.Despite strong experimental evidence in animal models, the transposition to humans remains limited. While current studies suggest an association between dysregulation and infertility, many clinical findings remain inconclusive. This underscores a critical gap: a lack of large-scale, controlled clinical studies capable of clarifying causal relationships and therapeutic potential. Additionally, while chronotherapy and chronobiotics have the potential to enhance fertility outcomes, their incorporation into reproductive medicine is still in its infancy.This monograph reviews the relationship between circadian disruption and impaired female fertility, while presenting strategies targeting the circadian system in order to reduce misalignment and optimize reproductive outcomes. |
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