Publicação
Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release
| Resumo: | The study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses. |
|---|---|
| Autores principais: | Pimenta, Andreia F. R. |
| Outros Autores: | Serro, Ana Paula; Paradiso, Patrizia; Saramago, Benilde; Colaço, Rogério |
| Assunto: | Ophthalmic lenses Controlled drug release |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| Idioma: | inglês |
| Origem: | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| _version_ | 1876663789282131968 |
|---|---|
| author | Pimenta, Andreia F. R. |
| author2 | Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
| author2_role | author author author author |
| author_facet | Pimenta, Andreia F. R. Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
| author_role | author |
| contributor_name_str_mv | Repositório Comum |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pimenta, Andreia F. R.\"},{\"Person.name\":\"Serro, Ana Paula\"},{\"Person.name\":\"Paradiso, Patrizia\"},{\"Person.name\":\"Saramago, Benilde\"},{\"Person.name\":\"Colaço, Rogério\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Comum |
| datacite.creators.creator.creatorName.fl_str_mv | Pimenta, Andreia F. R. Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
| datacite.date.Accepted.fl_str_mv | 2016-12-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2017-06-07T09:27:38Z |
| datacite.date.embargoed.fl_str_mv | 2017-06-07T09:27:38Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Ophthalmic lenses Controlled drug release |
| datacite.titles.title.fl_str_mv | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| dc.contributor.none.fl_str_mv | Repositório Comum |
| dc.creator.none.fl_str_mv | Pimenta, Andreia F. R. Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
| dc.date.Accepted.fl_str_mv | 2016-12-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2017-06-07T09:27:38Z |
| dc.date.embargoed.fl_str_mv | 2017-06-07T09:27:38Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.26/18482 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | PLOS |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Ophthalmic lenses Controlled drug release |
| dc.title.fl_str_mv | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://comum.rcaap.pt/bitstreams/4e08a664-8fdf-446d-b7ce-67789e9c6e05/download |
| funder_facet_str_mv | FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| id | em_9e21ee9b10353fcdd2d792e8cdb26abe |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.26/18482 |
| inst_facet_str | urn:organizationAcronym:em{{{_:::_}}}Egas Moniz - Cooperativa de Ensino Superior, CRL |
| instacron_str | em |
| institution | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| instname_str | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| language | eng |
| network_acronym_str | em |
| network_name_str | Egas Moniz - Cooperativa de Ensino Superior, CRL |
| oai_identifier_str | oai:comum.rcaap.pt:10400.26/18482 |
| organization_str_mv | urn:organizationAcronym:em |
| person_str_mv | Pimenta, Andreia F. R. Serro, Ana Paula Paradiso, Patrizia Saramago, Benilde Colaço, Rogério |
| publishDate | 2016 |
| publisher.none.fl_str_mv | PLOS |
| repo_facet_str | urn:repositoryAcronym:em{{{_:::_}}}Egas Moniz - Cooperativa de Ensino Superior, CRL |
| reponame_str | Egas Moniz - Cooperativa de Ensino Superior, CRL |
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| spelling | engPLOSpt_PTThe study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses.application/pdfpt_PTDiffusion-based design of multi-layered ophthalmic lenses for controlled drug releasePimenta, Andreia F. R.Serro, Ana PaulaParadiso, PatriziaSaramago, BenildeColaço, RogérioHostingInstitutionOrganizationalRepositório Comume-mailmailto:comum@rcaap.ptcomum@rcaap.ptISSNIsPartOf1932-6203DOIIsPartOf10.1371/journal.pone.01677282017-06-07T09:27:38Z2016-122016-12-01T00:00:00ZHandlehttp://hdl.handle.net/10400.26/18482http://purl.org/coar/access_right/c_abf2open accessOphthalmic lensesControlled drug release1419579 bytesFundação para a Ciência e a TecnologiaSURFACE MODIFICATIONS TO CONTROL DRUG RELEASE FROM THERAPEUTIC OPHTHALMIC LENSESCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaBIOTRIBOLOGICAL EFFECTS ON THE DRUG DELIVERY PERFORMANCE OF SOFT CONTACT LENS MATERIALSCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2016-12http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://comum.rcaap.pt/bitstreams/4e08a664-8fdf-446d-b7ce-67789e9c6e05/downloadPLoS ONE11(12)e0167728 |
| spellingShingle | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release Pimenta, Andreia F. R. Ophthalmic lenses Controlled drug release |
| status | SINGLETON |
| subject.fl_str_mv | Ophthalmic lenses Controlled drug release |
| title | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| title_full | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| title_fullStr | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| title_full_unstemmed | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| title_short | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| title_sort | Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release |
| topic | Ophthalmic lenses Controlled drug release |
| topic_facet | Ophthalmic lenses Controlled drug release |
| url | http://hdl.handle.net/10400.26/18482 |
| visible | 1 |
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