Publicação
Acute Kidney Injury post percutaneous coronary interventionand the volume of contrast administered
| Resumo: | Introduction: In patients who undergo percutaneous coronary intervention (PCI), contrast induced acute kidney injury is a common complication, with a prevalence of up to 10-15%, associated with an increase in morbidity and mortality, its prevention imperative. Scientific evidence expresses that the ratio between the median contrast volume administered (VolC) during PCI and the creatinine clearance (CrCl) is an independent predictor of AKI-IC development post PCI in patients with acute coronary syndrome (ACS). However, the optimal value remains controversial. This study aims to determine witch is the optimal value for the ratio VolC/CrCl, that allows the prevention of AKI-CI development in patients with ACS who undergo PCI. Methods: Retrospective observational study based on the information from the National register for acute coronary syndrome, that includes all patients with ACS, admitted to the Algarve Hospital center, between 1/1/2018 e 31/12/2020, that were submitted to PCI. We carried out descriptive, comparative, and inferential statistic as well as a multivariate analysis through logistic regression and optimal binning. Results: Sample essentially masculine (78,7%). Female sex associated with a higher incidence of AKI (22,76%) and mortality (11,25%) after PCI. Gender, being an ex-smoker and having renal insufficiency as past medical history appear as predictors of AKI development post PCI and, the development of AKI, is associated with increased mortality (56%). VolC/ClCreat of 2 favours the nonoccurrence of AKI post PCI. Conclusions: A ratio VolC/ClCreat of 2, even though it does not completely prevent the development of AKI-CI, it potentiates approximately five times the non-occurrence of AKI-CI when compared to its occurrence. |
|---|---|
| Autores principais: | Silva, Mónica |
| Outros Autores: | Costa, Hugo |
| Assunto: | Lesão renal aguda induzida por contraste Síndrome coronária aguda Intervenção coronária percutânea Rácio VolC/ClCr Contrast induced acute kidney injury Acute coronary syndrome Percutaneous coronary intervention Ratio VolC/ClCr |
| Ano: | 2026 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | USL Algarve |
| Idioma: | português |
| Origem: | Algarve Médico |
| Resumo: | Introduction: In patients who undergo percutaneous coronary intervention (PCI), contrast induced acute kidney injury is a common complication, with a prevalence of up to 10-15%, associated with an increase in morbidity and mortality, its prevention imperative. Scientific evidence expresses that the ratio between the median contrast volume administered (VolC) during PCI and the creatinine clearance (CrCl) is an independent predictor of AKI-IC development post PCI in patients with acute coronary syndrome (ACS). However, the optimal value remains controversial. This study aims to determine witch is the optimal value for the ratio VolC/CrCl, that allows the prevention of AKI-CI development in patients with ACS who undergo PCI. Methods: Retrospective observational study based on the information from the National register for acute coronary syndrome, that includes all patients with ACS, admitted to the Algarve Hospital center, between 1/1/2018 e 31/12/2020, that were submitted to PCI. We carried out descriptive, comparative, and inferential statistic as well as a multivariate analysis through logistic regression and optimal binning. Results: Sample essentially masculine (78,7%). Female sex associated with a higher incidence of AKI (22,76%) and mortality (11,25%) after PCI. Gender, being an ex-smoker and having renal insufficiency as past medical history appear as predictors of AKI development post PCI and, the development of AKI, is associated with increased mortality (56%). VolC/ClCreat of 2 favours the nonoccurrence of AKI post PCI. Conclusions: A ratio VolC/ClCreat of 2, even though it does not completely prevent the development of AKI-CI, it potentiates approximately five times the non-occurrence of AKI-CI when compared to its occurrence. |
|---|
Atividades financiadas
Não foram encontrados projetos financiados.