Publicação
In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications
| Resumo: | The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels. |
|---|---|
| Autores principais: | Martins, Eva |
| Outros Autores: | Reis, Rui L.; Silva, Tiago H. |
| Assunto: | Cytotoxicity Fish by-products Hydration Hydrogel In vivo assay Marine collagen Skin cosmetic formulation |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Católica Portuguesa |
| Idioma: | inglês |
| Origem: | Veritati - Repositório Institucional da Universidade Católica Portuguesa |
| _version_ | 1877783785913712640 |
|---|---|
| author | Martins, Eva |
| author2 | Reis, Rui L. Silva, Tiago H. |
| author2_role | author author |
| author_facet | Martins, Eva Reis, Rui L. Silva, Tiago H. |
| author_role | author |
| contributor_name_str_mv | Veritati |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Martins, Eva\"},{\"Person.name\":\"Reis, Rui L.\"},{\"Person.name\":\"Silva, Tiago H.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Veritati |
| datacite.creators.creator.creatorName.fl_str_mv | Martins, Eva Reis, Rui L. Silva, Tiago H. |
| datacite.date.Accepted.fl_str_mv | 2023-01-17T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-03-14T11:03:52Z |
| datacite.date.embargoed.fl_str_mv | 2023-03-14T11:03:52Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Cytotoxicity Fish by-products Hydration Hydrogel In vivo assay Marine collagen Skin cosmetic formulation |
| datacite.titles.title.fl_str_mv | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| dc.contributor.none.fl_str_mv | Veritati |
| dc.creator.none.fl_str_mv | Martins, Eva Reis, Rui L. Silva, Tiago H. |
| dc.date.Accepted.fl_str_mv | 2023-01-17T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-03-14T11:03:52Z |
| dc.date.embargoed.fl_str_mv | 2023-03-14T11:03:52Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.14/40564 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Cytotoxicity Fish by-products Hydration Hydrogel In vivo assay Marine collagen Skin cosmetic formulation |
| dc.title.fl_str_mv | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ucp.pt/bitstreams/04ea52c6-5944-4aa5-92bc-e083f3d80d47/download |
| id | veritati_98af21bee0e8d89ec3e0086429fdd7cd |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.14/40564 |
| inst_facet_str | urn:organizationAcronym:ucp{{{_:::_}}}Universidade Católica Portuguesa |
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| institution | Universidade Católica Portuguesa |
| instname_str | Universidade Católica Portuguesa |
| language | eng |
| network_acronym_str | veritati |
| network_name_str | Veritati - Repositório Institucional da Universidade Católica Portuguesa |
| oai_identifier_str | oai:repositorio.ucp.pt:10400.14/40564 |
| organization_str_mv | urn:organizationAcronym:ucp |
| person_str_mv | Martins, Eva Reis, Rui L. Silva, Tiago H. |
| publishDate | 2023 |
| repo_facet_str | urn:repositoryAcronym:veritati{{{_:::_}}}Veritati - Repositório Institucional da Universidade Católica Portuguesa |
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| spelling | engpt_PTThe industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extraction of this protein from fish skins has been established for different species. Using this approach, we investigated the integration of marine collagen (COLRp_I) extracted from the skin of the Greenland halibut as an active ingredient in a cosmetic hydrogel formulation. In this study, extracts of marine collagen at concentrations up to 10 mg/mL showed a non-cytotoxic effect when cultured with fibroblast cells for 3 days. In addition, marine collagen extract, when incorporated into a cosmetic hydrogel formulation, met criterion A of ISO 11930:2019 regarding the efficacy of the preservative system (challenge test). In addition, the cosmetic formulations based on marine collagen at dosages of 0.1, 0.25 and 0.5% were tested in a clinical study on the skin of the forearms of 23 healthy volunteers, showing a sightly hydration effect, suggesting its potential for beauty applications. Moreover, this work illustrates that the circular economy concept applied to the fish processing industry can represent important benefits, at innovation, environmental and economic levels.application/pdfpt_PTIn vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applicationsMartins, EvaReis, Rui L.Silva, Tiago H.HostingInstitutionOrganizationalVeritatie-mailmailto:repositorio@ucp.ptrepositorio@ucp.ptISSNIsPartOf1660-3397DOIIsPartOf10.3390/md210200572023-03-14T11:03:52Z2023-01-172023-01-17T00:00:00ZHandlehttp://hdl.handle.net/10400.14/40564http://purl.org/coar/access_right/c_abf2open accessCytotoxicityFish by-productsHydrationHydrogelIn vivo assayMarine collagenSkin cosmetic formulation2699863 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2023-01-17http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ucp.pt/bitstreams/04ea52c6-5944-4aa5-92bc-e083f3d80d47/downloadMarine Drugs212 |
| spellingShingle | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications Martins, Eva Cytotoxicity Fish by-products Hydration Hydrogel In vivo assay Marine collagen Skin cosmetic formulation |
| status | SINGLETON |
| subject.fl_str_mv | Cytotoxicity Fish by-products Hydration Hydrogel In vivo assay Marine collagen Skin cosmetic formulation |
| title | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| title_full | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| title_fullStr | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| title_full_unstemmed | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| title_short | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| title_sort | In vivo skin hydrating efficacy of fish collagen from greenland halibut as a high-value active ingredient for cosmetic applications |
| topic | Cytotoxicity Fish by-products Hydration Hydrogel In vivo assay Marine collagen Skin cosmetic formulation |
| topic_facet | Cytotoxicity Fish by-products Hydration Hydrogel In vivo assay Marine collagen Skin cosmetic formulation |
| url | http://hdl.handle.net/10400.14/40564 |
| visible | 1 |
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