Publicação
Is decellularized rabbit dermis a viable option for skin wound healing and regeneration?
| Resumo: | Burn wounds remain a significant challenge in medical care, requiring effective wound coverage to restore the skin barrier and promote healing or support skin reconstruction. The use of autologous grafts as substitutes is still the standard treatment, however, it is not suitable for deep and extensive burns (1). Decellularized skin allografts and xenografts have emerged as suitable options, using decellularization to remove the immunogenic material present in the tissue while preserving the ECM components and interesting biomolecules (3). Considering that xenografts source availability is significantly higher and free of ethical concerns, this study describes for the first time a protocol for decellularizing rabbit dermis, leveraging a valuable agro-food by-product which exceeds 5000 skins/day at the world-leading company Cortadoria Nacional de Pêlo, and studies its potential for skin regeneration. |
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| Autores principais: | Rosadas, Marta |
| Outros Autores: | Sousa, Teresa; Sousa, Alda; Ribeiro, Viviana P.; Oliveira, Ana L. |
| Assunto: | Biocompatibility Biological material in vitro tests Leachables Skin Wound healing |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Católica Portuguesa |
| Idioma: | inglês |
| Origem: | Veritati - Repositório Institucional da Universidade Católica Portuguesa |
| Resumo: | Burn wounds remain a significant challenge in medical care, requiring effective wound coverage to restore the skin barrier and promote healing or support skin reconstruction. The use of autologous grafts as substitutes is still the standard treatment, however, it is not suitable for deep and extensive burns (1). Decellularized skin allografts and xenografts have emerged as suitable options, using decellularization to remove the immunogenic material present in the tissue while preserving the ECM components and interesting biomolecules (3). Considering that xenografts source availability is significantly higher and free of ethical concerns, this study describes for the first time a protocol for decellularizing rabbit dermis, leveraging a valuable agro-food by-product which exceeds 5000 skins/day at the world-leading company Cortadoria Nacional de Pêlo, and studies its potential for skin regeneration. |
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Atividades financiadas
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