Publicação
Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study
| Resumo: | Long-term lead (Pb) exposure alters the normal development of the nervous system and physiology. It affects multiple organ systems, causing hypertension, cardiorespiratory dysfunction, being a well-known neurotoxin, inducing changes in neurogenesis, neurodegeneration, and glial cells. However, studies of the developmental effects of lead and its outcomes throughout life are lacking. Determine morphofunctional, behavioral, and cognitive developmental effects of long-term lead exposure at three different ages. Wistar rats were exposed to a Pb-acetate solution from fetal period until adulthood and compared to a non-exposed control group. General behavior and cognitive skills were evaluated by behavioral tests and physiological data and cardiorespiratory reflexes measured. Neurodegeneration, neuroinflammation, and synaptic activity were assessed by immunohistochemistry. Lead exposure caused long-lasting anxiety-like behavior and strong long-term memory impairment without changes in locomotor and exploratory activity. Hypertension was observed at all time points, concomitant with baroreflex impairment and increased chemoreflex sensitivity. Persistent neuroinflammation, transient synaptic overexcitation without neurodegeneration was observed. Long-term Pb exposure, since fetal period, causes long-lasting anxiety-like behavior, concomitant with hypertension, without general motor skills impairment. Synaptic overexcitation, reactive astrogliosis, and microgliosis could underlie behavioral and long-term memory changes, which might have been caused during developmental phases and consolidated during adulthood. Also, alterations observed in the cardiorespiratory reflexes can explain persistent hypertension. This longitudinal study identifies and characterizes lead toxicity nature and magnitude, important to devise and test potential interventions to attenuate the long-term harmful effects of lead on the nervous and cardiovascular systems. |
|---|---|
| Autores principais: | Shvachiy, Liana |
| Outros Autores: | Geraldes, Vera; Amaro-Leal, Ângela; Rocha, Isabel |
| Assunto: | Lead exposure Anxiety-like behavior Cognitive impairment Neuroinflammation Hypertension Cardiorespiratory impairment |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1877774268592291840 |
|---|---|
| author | Shvachiy, Liana |
| author2 | Geraldes, Vera Amaro-Leal, Ângela Rocha, Isabel |
| author2_role | author author author |
| author_facet | Shvachiy, Liana Geraldes, Vera Amaro-Leal, Ângela Rocha, Isabel |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Shvachiy, Liana\",\"Person.identifier.cienciaID\":\"CE1E-41FB-0835\",\"Person.identifier.orcid\":\"0000-0002-4576-0017\"},{\"Person.name\":\"Geraldes, Vera\",\"Person.identifier.cienciaID\":\"D51D-E96C-1633\",\"Person.identifier.orcid\":\"0000-0003-1275-3459\",\"Person.identifier.researcherID\":\"M-4137-2013\"},{\"Person.name\":\"Amaro-Leal, Ângela\"},{\"Person.name\":\"Rocha, Isabel\",\"Person.identifier.orcid\":\"0000-0002-7582-0893\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Shvachiy, Liana Geraldes, Vera Amaro-Leal, Ângela Rocha, Isabel |
| datacite.date.Accepted.fl_str_mv | 2020-01-29T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-03-19T11:49:55Z |
| datacite.date.embargoed.fl_str_mv | 2020-03-19T11:49:55Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Lead exposure Anxiety-like behavior Cognitive impairment Neuroinflammation Hypertension Cardiorespiratory impairment |
| datacite.titles.title.fl_str_mv | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Shvachiy, Liana Geraldes, Vera Amaro-Leal, Ângela Rocha, Isabel |
| dc.date.Accepted.fl_str_mv | 2020-01-29T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-03-19T11:49:55Z |
| dc.date.embargoed.fl_str_mv | 2020-03-19T11:49:55Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/42501 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Springer |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Lead exposure Anxiety-like behavior Cognitive impairment Neuroinflammation Hypertension Cardiorespiratory impairment |
| dc.title.fl_str_mv | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Long-term lead (Pb) exposure alters the normal development of the nervous system and physiology. It affects multiple organ systems, causing hypertension, cardiorespiratory dysfunction, being a well-known neurotoxin, inducing changes in neurogenesis, neurodegeneration, and glial cells. However, studies of the developmental effects of lead and its outcomes throughout life are lacking. Determine morphofunctional, behavioral, and cognitive developmental effects of long-term lead exposure at three different ages. Wistar rats were exposed to a Pb-acetate solution from fetal period until adulthood and compared to a non-exposed control group. General behavior and cognitive skills were evaluated by behavioral tests and physiological data and cardiorespiratory reflexes measured. Neurodegeneration, neuroinflammation, and synaptic activity were assessed by immunohistochemistry. Lead exposure caused long-lasting anxiety-like behavior and strong long-term memory impairment without changes in locomotor and exploratory activity. Hypertension was observed at all time points, concomitant with baroreflex impairment and increased chemoreflex sensitivity. Persistent neuroinflammation, transient synaptic overexcitation without neurodegeneration was observed. Long-term Pb exposure, since fetal period, causes long-lasting anxiety-like behavior, concomitant with hypertension, without general motor skills impairment. Synaptic overexcitation, reactive astrogliosis, and microgliosis could underlie behavioral and long-term memory changes, which might have been caused during developmental phases and consolidated during adulthood. Also, alterations observed in the cardiorespiratory reflexes can explain persistent hypertension. This longitudinal study identifies and characterizes lead toxicity nature and magnitude, important to devise and test potential interventions to attenuate the long-term harmful effects of lead on the nervous and cardiovascular systems. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/93352c17-0b14-4903-aac6-bd65718819b5/download |
| funder_facet_str_mv | FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| funding.identifier_str_mv | SFRH/BPD/119315/2016 |
| funding.name_str_mv | OE |
| funding_str_mv | SFRH/BPD/119315/2016 info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F119315%2F2016/PT |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10451/42501 |
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| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/42501 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Shvachiy, Liana Shvachiy, Liana https://www.ciencia-id.pt/CE1E-41FB-0835 CE1E-41FB-0835 http://orcid.org/0000-0002-4576-0017 0000-0002-4576-0017 Geraldes, Vera Geraldes, Vera https://www.ciencia-id.pt/D51D-E96C-1633 D51D-E96C-1633 http://orcid.org/0000-0003-1275-3459 0000-0003-1275-3459 Amaro-Leal, Ângela Rocha, Isabel Rocha, Isabel http://orcid.org/0000-0002-7582-0893 0000-0002-7582-0893 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Springer |
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| spelling | engSpringerpt_PTLong-term lead (Pb) exposure alters the normal development of the nervous system and physiology. It affects multiple organ systems, causing hypertension, cardiorespiratory dysfunction, being a well-known neurotoxin, inducing changes in neurogenesis, neurodegeneration, and glial cells. However, studies of the developmental effects of lead and its outcomes throughout life are lacking. Determine morphofunctional, behavioral, and cognitive developmental effects of long-term lead exposure at three different ages. Wistar rats were exposed to a Pb-acetate solution from fetal period until adulthood and compared to a non-exposed control group. General behavior and cognitive skills were evaluated by behavioral tests and physiological data and cardiorespiratory reflexes measured. Neurodegeneration, neuroinflammation, and synaptic activity were assessed by immunohistochemistry. Lead exposure caused long-lasting anxiety-like behavior and strong long-term memory impairment without changes in locomotor and exploratory activity. Hypertension was observed at all time points, concomitant with baroreflex impairment and increased chemoreflex sensitivity. Persistent neuroinflammation, transient synaptic overexcitation without neurodegeneration was observed. Long-term Pb exposure, since fetal period, causes long-lasting anxiety-like behavior, concomitant with hypertension, without general motor skills impairment. Synaptic overexcitation, reactive astrogliosis, and microgliosis could underlie behavioral and long-term memory changes, which might have been caused during developmental phases and consolidated during adulthood. Also, alterations observed in the cardiorespiratory reflexes can explain persistent hypertension. This longitudinal study identifies and characterizes lead toxicity nature and magnitude, important to devise and test potential interventions to attenuate the long-term harmful effects of lead on the nervous and cardiovascular systems.application/pdfpt_PTPersistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal studyPersonalShvachiy, LianaDSpacehttp://dspace.org/items/9b1685ff-e083-470c-800b-23135db7e229DSpacehttp://dspace.org/items/9b1685ff-e083-470c-800b-23135db7e229ShvachiyLianaCiência IDhttps://www.ciencia-id.ptCE1E-41FB-0835ORCIDhttp://orcid.org0000-0002-4576-0017PersonalGeraldes, VeraDSpacehttp://dspace.org/items/16b49724-d060-4106-955d-d211cba44c12DSpacehttp://dspace.org/items/16b49724-d060-4106-955d-d211cba44c12GeraldesVeraCiência IDhttps://www.ciencia-id.ptD51D-E96C-1633ORCIDhttp://orcid.org0000-0003-1275-3459Researcher IDhttps://www.researcherid.comM-4137-2013Amaro-Leal, ÂngelaPersonalRocha, IsabelDSpacehttp://dspace.org/items/472714e8-fa6c-4d7b-9c4d-d6f5b55e39f4DSpacehttp://dspace.org/items/472714e8-fa6c-4d7b-9c4d-d6f5b55e39f4rochaisabelORCIDhttp://orcid.org0000-0002-7582-0893HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@ulisboa.ptrepositorio@ulisboa.ptISSNIsPartOf1029-8428DOIIsPartOf10.1007/s12640-020-00162-82020-03-19T11:49:55Z2020-01-292020-01-29T00:00:00ZHandlehttp://hdl.handle.net/10451/42501http://purl.org/coar/access_right/c_16ecrestricted accessLead exposureAnxiety-like behaviorCognitive impairmentNeuroinflammationHypertensionCardiorespiratory impairment1901859 bytesFundação para a Ciência e a TecnologiaBreast cancer chemotherapy: sympathetic overexcitation as an earlier complementary biomarker of cardiotoxicityinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F119315%2F2016/PTSFRH/BPD/119315/2016OECrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/93352c17-0b14-4903-aac6-bd65718819b5/downloadNeurotoxicity Research |
| spellingShingle | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study Shvachiy, Liana Lead exposure Anxiety-like behavior Cognitive impairment Neuroinflammation Hypertension Cardiorespiratory impairment |
| status | SINGLETON |
| subject.fl_str_mv | Lead exposure Anxiety-like behavior Cognitive impairment Neuroinflammation Hypertension Cardiorespiratory impairment |
| title | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| title_full | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| title_fullStr | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| title_full_unstemmed | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| title_short | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| title_sort | Persistent effects on cardiorespiratory and nervous systems induced by long-term lead exposure : results from a longitudinal study |
| topic | Lead exposure Anxiety-like behavior Cognitive impairment Neuroinflammation Hypertension Cardiorespiratory impairment |
| topic_facet | Lead exposure Anxiety-like behavior Cognitive impairment Neuroinflammation Hypertension Cardiorespiratory impairment |
| url | http://hdl.handle.net/10451/42501 |
| visible | 1 |